Chemical biology tools for protein labelling: insights into cell-cell communication.
Chemical biology tools for protein labelling: insights into cell-cell communication.
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DOI：
10.1042/bcj20220309
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发表时间：
2023-09-27
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
多细胞生物需要精心策划细胞类型和组织之间和内部的通信，许多单细胞生物也能感知它们的背景和环境，有时会协调它们的反应。本文综述了化学生物学在发现和探索细胞间通讯机制方面的贡献。我们专注于在细胞环境中标记蛋白质的化学工具，以及这些工具如何应用于破译信号分子的靶受体，原位标记感兴趣的受体以了解其生物学，提供蛋白质活性或下游信号传导途径中的相互作用的读数，或发现跨细胞界面的蛋白质-蛋白质相互作用。
Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell–cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein–protein interactions across cell–cell interfaces.
DOI：
10.1073/pnas.2118227119
发表时间：
2022-03-08
影响因子：
11.1
作者：
Weigert Muñoz A;Hoyer E;Schumacher K;Grognot M;Taute KM;Hacker SM;Sieber SA;Jung K
通讯作者：
Jung K
影响因子：
4.1
作者：
Field, Devon H. H.;White, Jack S. S.;Warriner, Stuart L. L.;Wright, Megan H. H.
通讯作者：
Wright, Megan H. H.