Beneficial long-term effect of intracoronary perfluorochemical on infarct size and ventricular function in a canine reperfusion model.
Beneficial long-term effect of intracoronary perfluorochemical on infarct size and ventricular function in a canine reperfusion model.
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冠状动脉内全氟化学物质对犬再灌注模型中梗死面积和心室功能的长期有益影响。
DOI：
10.1016/s0735-1097(87)80311-x
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发表时间：
1987
影响因子：
24
通讯作者：
Virmani,R
中科院分区：
文献类型：
--
作者：
Forman,MB;Puett,DW;Wilson,BH;Vaughn,WK;Friesinger,GC;Virmani,R
在再灌注后不久给予一种可以增强心肌挽救的药物将具有重要的临床应用。本研究的目的是在2周闭胸犬模型中评估全氟化合物Fluosol DA 20%对梗死面积、梗死形态、心室异位活动和系列局部心室功能的长期影响。在近端左前降支动脉闭塞90分钟后，动物在20至30分钟内随机接受15 ml/kg体重的含氧Fluosol DA（n = 9）或盐水溶液（n = 9）冠状动脉内给药。两组的血流动力学参数相似，但治疗组在输注后即刻出现短暂的左心室Ailing压升高。全氟化学品治疗组动物的冠状动脉大小以危险区的百分比表示时显著减小（10.8 ± 1.8%对28.9 ± 5.5%，p < 0.02）或占总左心室的百分比（3.7 ± 1%对10.8 ± 8%，p < 0.006）。这与再灌注后2周时受损区域的径向缩短的更大改善相关（15.3 ± 2.8%对5.2 ± 2.1%，p < 0.01）。组织学检查显示，治疗组动物愈合充分，边界区域肿胀单核细胞数量增加。霍尔特心电图记录显示两组的室性异位搏动频率较低。这项研究表明，全氟化合物，Fluosol DA，可能是一个潜在的有用的代理，在成功的再灌注后，提高心肌挽救。
The administration of a drug soon after reperfusion that could enhance myocardial salvage would have important clinical application. The aim of this study was to assess the long-term effect of the perfluorochemical, Fluosol DA 20%, on infarct size, infarct morphology, ventricular ectopic activity and serial regional ventricular function in a 2 week closed chest canine model. After 90 minutes of proximal left anterior descending artery occlusion, animals randomly received either oxygenated Fluosol DA (n = 9) or saline solution (n = 9) intracoronary at 15 ml/kg body weight over 20 to 30 minutes. Hemodynamic variables were similar in the two groups except for transient elevation of left ventricular Ailing pressure immediately after infusion in the treated group.Infarct size was markedly reduced in the perfluoro-chemical-treated animals when expressed as a percent of the risk region (10.8 ± 1.8% versus 28.9 ± 5.5%, p < 0.02) or as a percent of the total left ventricle (3.7 ± 1% versus 10.8 ± 8%, p < 0.006). This was associated with greater improvement in radial shortening in the jeopardized zone at 2 weeks after reperfusion (15.3 ± 2.8% versus 5.2 ± 2.1%, p < 0.01). Histologic examination revealed adequate healing in the treated animals with an increased number of swollen mononuclear cells in the border zones. Holter electrocardiographic recordings demonstrated a low frequency of ventricular ectopic beats in both groups. This study suggests that the perfluorochemical, Fluosol DA, may be a potentially useful agent in enhancing myocardial salvage after successful reperfusion.
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人工血液替代品导致吞噬细胞迁移瘫痪。
影响因子：
20.3
作者：
T. Lane;G. Lamkin
通讯作者：
G. Lamkin
在犬再灌注准备中使用冠状动脉内全氟化物减少梗塞面积。
影响因子：
37.8
作者：
M. Forman;S. Bingham;H. Kopelman;C. Wehr;M. Sandler;F. Kolodgie;W. Vaughn;G. Friesinger;R. Virmani
通讯作者：
R. Virmani
影响因子：
24
作者：
K. Karsch;M. Hofmann;K. Rentrop;H. Blanke;W. Schaper
通讯作者：
W. Schaper
DOI：
--
发表时间：
1983-04
期刊：
The American journal of pathology
影响因子：
--
作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
通讯作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
急性心肌梗死冠状动脉内输注链激酶后受损心肌的功能改善。
DOI：
10.1172/jci110987
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Stack,RS;Phillips3rd,HR;Grierson,DS;Behar,VS;Kong,Y;Peter,RH;Swain,JL;GreenfieldJr,JC
通讯作者：
GreenfieldJr,JC