Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion.
Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion.
复制标题
在犬再灌注准备中使用冠状动脉内全氟化物减少梗塞面积。
作者：
M. Forman;S. Bingham;H. Kopelman;C. Wehr;M. Sandler;F. Kolodgie;W. Vaughn;G. Friesinger;R. Virmani
在 20 只接受 11/2 小时近端左前降支闭塞的麻醉闭胸犬中，研究了低剂量 (15 ml/kg) 冠状动脉内全氟化学物质 (Fluosol-DA) 对梗塞面积、局部心肌血流量和心室功能的影响。在该准备中，用纤溶疗法模拟再灌注。这些动物被随机分配到两个治疗组之一，并给予 15 ml/kg 冠状动脉内含氧全氟化合物 (n = 9) 或盐水 (n = 11)。在基线、闭塞后1小时和再灌注后24小时获得对比心室造影图，并用径向缩短分数法进行分析。用放射性微球测量局部心肌血流量。 24小时时，用monastryl蓝染色确定体内危险区域，并在用氯化三苯基四唑孵育左心室切片后估计坏死区域。在实验过程中，心率、血压、肺毛细血管楔压或 dP/dt 没有显着变化。在全氟化物治疗组中，梗塞面积显着减小（p 小于 0.02），以占左心室总质量的百分比（7.9 +/- 1.7% vs 14.7 +/- 2.5%）和占危险面积的百分比（20.1 +/- 5.0% vs 46.8 +/- 8.5%）表示。这与再灌注后 24 小时危险区缩短分数的显着改善相关。尽管全氟化物治疗组再灌注后立即中央缺血区和侧部危险区域的心内膜血流量显着增加，但再灌注后 1 小时没有发现差异。（摘要截断为 250 字）
The effect of low-dose (15 ml/kg) intracoronary perfluorochemical (Fluosol-DA) on infarct size, regional myocardial blood flow, and ventricular function was studied in 20 anesthetized closed-chest dogs subjected to 11/2 hr of proximal left anterior descending occlusion. In this preparation reperfusion was simulated with fibrinolytic therapy. The animals were randomly assigned one of two treatment groups and given 15 ml/kg of either oxygenated intracoronary perfluorochemical (n = 9) or saline (n = 11). Contrast ventriculograms were obtained at baseline, 1 hr after occlusion, and at 24 hr after reperfusion and were analyzed with a radial fractional shortening method. Regional myocardial blood flow was measured with radioactive microspheres. At 24 hr the area at risk was defined in vivo with monastryl blue staining and the area of necrosis was estimated after incubation of left ventricular slices with triphenyltetrazolium chloride. No significant changes were noted in heart rate, blood pressure, pulmonary capillary wedge pressure, or dP/dt during the experimental protocol. Infarct size was significantly reduced (p less than .02) in the perfluorochemical-treated group, both when expressed as a percentage of the total left ventricular mass (7.9 +/- 1.7% vs 14.7 +/- 2.5%) and as a percentage of the area at risk (20.1 +/- 5.0% vs 46.8 +/- 8.5%). This was associated with significant improvement in fractional shortening in the jeopardized zone at 24 hr after reperfusion. Although endocardial blood flow was significantly greater in the central ischemic zone and lateral region at risk immediately after reperfusion in the perfluorochemical-treated group, no difference was found 1 hr after reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
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实验性心肌梗死期间前列环素对缺血心肌的挽救作用。
影响因子：
24
作者：
Melin,JA;Becker,LC
通讯作者：
Becker,LC
DOI：
--
发表时间：
1983-04
期刊：
The American journal of pathology
影响因子：
--
作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
通讯作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
急性心肌梗死冠状动脉内输注链激酶后受损心肌的功能改善。
DOI：
10.1172/jci110987
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Stack,RS;Phillips3rd,HR;Grierson,DS;Behar,VS;Kong,Y;Peter,RH;Swain,JL;GreenfieldJr,JC
通讯作者：
GreenfieldJr,JC
碳氟化合物可减少冠状动脉闭塞后的心肌缺血损伤。
DOI：
10.1126/science.7466402
发表时间：
1981
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Glogar,DH;Kloner,RA;Muller,J;DeBoer,LW;Braunwald,E;ClarkJr,LC
通讯作者：
ClarkJr,LC
通过测量心肌内气体张力评估静脉内氟碳化合物在强化供氧期间和不强化期间对急性心肌缺血损伤的影响。
影响因子：
4.8
作者：
Rude,RE;Glogar,D;Khuri,SF;Kloner,RA;Karaffa,S;Muller,JE;ClarkJr,LC;Braunwald,E
通讯作者：
Braunwald,E