Hormonal modulation of endothelial NO production.
Hormonal modulation of endothelial NO production.
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DOI：
10.1007/s00424-010-0797-1
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发表时间：
2010-05
影响因子：
4.5
通讯作者：
Miller, Virginia M.
中科院分区：
文献类型：
--
作者：
Duckles, Sue P.;Miller, Virginia M.
自从内皮源性舒张因子的发现和随后一氧化氮（NO）作为内皮依赖性舒张的主要介质的鉴定以来，研究集中于调节NO水平的化学和物理刺激。激素代表一类可溶的、广泛循环的化学因子，其通过酶的磷酸化对内皮型一氧化氮合酶（eNOS）的活性的快速作用和通过eNOS蛋白量的变化的长期调节来影响NO的产生。增加NO产生的激素包括雌激素、孕酮、胰岛素和生长激素，它们通过这两种常见的机制来实现。相反，一些激素，包括糖皮质激素，孕酮和催乳素，降低NO的生物利用度。所涉及的机制包括与eNOS基因上的阻遏物反应元件结合，竞争具有正基因组作用的激素共同的辅助调节剂，调节eNOS辅助因子，减少eNOS的底物，以及增加氧源性自由基的产生。激素本身的反馈调节以及NO调节激素释放的能力提供了第二层次的复杂性，这也有助于NO水平的变化。这些对eNOS的影响和NO产生的变化可能会导致男性和女性中与衰老、妊娠、应激和代谢紊乱相关的心血管疾病的危险因素、表现和治疗的变化。
Since the discovery of endothelium-derived relaxing factor and the subsequent identification of nitric oxide (NO) as the primary mediator of endothelium-dependent relaxations, research has focused on chemical and physical stimuli that modulate NO levels. Hormones represent a class of soluble, widely circulating chemical factors that impact production of NO both by rapid effects on the activity of endothelial nitric oxide synthase (eNOS) through phosphorylation of the enzyme and longer term modulation through changes in amount of eNOS protein. Hormones that increase NO production including estrogen, progesterone, insulin, and growth hormone do so through both of these common mechanisms. In contrast, some hormones, including glucocorticoids, progesterone, and prolactin, decrease NO bioavailability. Mechanisms involved include binding to repressor response elements on the eNOS gene, competing for co-regulators common to hormones with positive genomic actions, regulating eNOS co-factors, decreasing substrate for eNOS, and increasing production of oxygen-derived free radicals. Feedback regulation by the hormones themselves as well as the ability of NO to regulate hormonal release provides a second level of complexity that can also contribute to changes in NO levels. These effects on eNOS and changes in NO production may contribute to variability in risk factors, presentation of and treatment for cardiovascular disease associated with aging, pregnancy, stress, and metabolic disorders in men and women.
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影响因子：
15.9
作者：
Cusi, K;Maezono, K;Mandarino, LJ
通讯作者：
Mandarino, LJ
DOI：
10.1080/10253890802506409
发表时间：
2009-05
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Biddie SC;Hager GL
通讯作者：
Hager GL
DOI：
10.1152/ajpheart.00029.2003
发表时间：
2003-09-01
影响因子：
4.8
作者：
Chatrath, R;Ronningen, KL;Miller, VM
通讯作者：
Miller, VM
影响因子：
--
作者：
CRITCHLOW, V;BARSELA, M;LIPSCOMB, HS
通讯作者：
LIPSCOMB, HS
DOI：
10.1097/01.gme.0000097847.95550.e3
发表时间：
2004-05-01
影响因子：
2.7
作者：
Chataigneau, T;Zerr, M;Schini-Kerth, VB
通讯作者：
Schini-Kerth, VB