Selectins: Novel Receptors that Mediate Leukocyte Adhesion During Inflammation
Selectins: Novel Receptors that Mediate Leukocyte Adhesion During Inflammation
复制标题
选择素：炎症期间介导白细胞粘附的新型受体
作者：
R. McEver
Membrane glycoproteins play essential roles in cell-cell and cell-matrix interactions during the hemostatic and inflammatory responses to tissue injury. During hemostasis, platelets express many receptors that support adhesion, spreadi.g, and aggregation at sites of vascular damage (1). During inflammation, receptors on leukocytes, platelets, and endotielium promote cellular interactions, resulting in directed migration of leukocytes into infected or injured tissues (2, 3). This group of adhesion molecules includes members of the immunoglobulin (tg) superfamily, the integrin family, and, the subject of this review, the recently described selectin family. Tb date, three selectins have been identified: LAM-1, ELAM-I, and GMP-14A @-8). Thble 1 summarizes some of the properties of these proteins and lists alternative names used in the literature. All three molecules mediate interactionS of leukocytes with the blood vessel wall. The name selectins was proposed because these receptors promote selective cell-cell interactions and because they a1e hypothesized to mediate adhesion by lectintype intr:ractions with oligosaccharides on target cells. An alternative term, LEC-CAMs, has also been suggested (9). In this review, lt will summanze structural and functional features of the selectins, mention other adhesion molecules which may operate in concert with them, and discuss certain pathologic states. in which the selectins may participate.
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唾液酸参与内皮细胞器官特异性淋巴细胞再循环。
DOI：
10.1126/science.4001928
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Rosen,SD;Singer,MS;Yednock,TA;Stoolman,LM
通讯作者：
Stoolman,LM
影响因子：
4.4
作者：
T. Tedder;Ann C. Penta;H. Levine;A. Freedman
通讯作者：
T. Tedder;Ann C. Penta;H. Levine;A. Freedman
影响因子：
4.4
作者：
D. Lewinsohn;R. Bargatze;E. Butcher
通讯作者：
D. Lewinsohn;R. Bargatze;E. Butcher
DOI：
10.1016/s0021-9258(18)81901-9
发表时间：
1989-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
R. Hattori;K. Hamilton;R. McEver;P. J. Sims
通讯作者：
R. Hattori;K. Hamilton;R. McEver;P. J. Sims
编码淋巴细胞和中性粒细胞的人白细胞粘附分子 1 (TQ1、Leu-8) 的基因结构。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ord,DC;Ernst,TJ;Zhou,LJ;Rambaldi,A;Spertini,O;Griffin,J;Tedder,TF
通讯作者：
Tedder,TF