Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure.
Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure.
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DOI：
10.1101/lm.053621.122
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发表时间：
2022-12
影响因子：
2
通讯作者：
Smith, Rachel J.
中科院分区：
文献类型：
--
作者：
Jones, Bradley O.;Cruz, Adelis M.;Kim, Tabitha H.;Spencer, Haley F.;Smith, Rachel J.
习惯理论上在强迫性可卡因寻求中起着关键作用，但评估静脉注射（IV）可卡因的习惯性反应的方法有限。我们开发了一种新的结果贬值程序来区分目标导向的习惯性反应在可卡因寻求大鼠。该程序暂时消除了减值，不需要额外的培训，允许在不同的时间点重复测试。在训练雄性大鼠自我施用IV可卡因后，我们在10分钟的消退测试之前通过实验者施用IV可卡因（“饱腹感”程序）来贬低药物结果。许多老鼠对结果贬值很敏感，这是目标导向反应的标志。当给予实验者给予的可卡因剂量与自我给药期间的饱腹感水平相匹配或超过饱腹感水平时，这些动物的反应减少。然而，其他大鼠对实验者给予的可卡因不敏感，这表明它们的反应是习惯性的。重要的是，产生目标导向反应的强化时间表和神经操纵（即，比率时间表或背外侧纹状体损伤）引起对结果贬值的敏感性，而产生习惯性反应的强化时间表和神经操作（即，间隔时间表或背内侧纹状体病变）引起的不敏感。基于满足的结果贬值是一种创新的新工具，剖析神经和行为机制的基础上，IV可卡因寻求行为。
Habits are theorized to play a key role in compulsive cocaine seeking, yet there is limited methodology for assessing habitual responding for intravenous (IV) cocaine. We developed a novel outcome devaluation procedure to discriminate goal-directed from habitual responding in cocaine-seeking rats. This procedure elicits devaluation temporarily and requires no additional training, allowing repeated testing at different time points. After training male rats to self-administer IV cocaine, we devalued the drug outcome via experimenter-administered IV cocaine (a “satiety” procedure) prior to a 10-min extinction test. Many rats were sensitive to outcome devaluation, a hallmark of goal-directed responding. These animals reduced responding when given a dose of experimenter-administered cocaine that matched or exceeded satiety levels during self-administration. However, other rats were insensitive to experimenter-administered cocaine, suggesting their responding was habitual. Importantly, reinforcement schedules and neural manipulations that produce goal-directed responding (i.e., ratio schedules or dorsolateral striatum lesions) caused sensitivity to outcome devaluation, whereas reinforcement schedules and neural manipulations that produce habitual responding (i.e., interval schedules or dorsomedial striatum lesions) caused insensitivity. Satiety-based outcome devaluation is an innovative new tool to dissect the neural and behavioral mechanisms underlying IV cocaine-seeking behavior.
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影响因子：
2.7
作者：
DOUGHERTY, J;PICKENS, R
通讯作者：
PICKENS, R
DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A
DOI：
10.1080/14640748308400912
发表时间：
1983-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
DICKINSON, A;NICHOLAS, DJ;ADAMS, CD
通讯作者：
ADAMS, CD
DOI：
10.1037/0097-7403.21.3.203
发表时间：
1995-07-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
BALLEINE, BW;GARNER, C;DICKINSON, A
通讯作者：
DICKINSON, A
寻求习惯性酒精：建模从休闲饮酒到成瘾的过渡。
影响因子：
8.2
作者：
Barker, Jacqueline M.;Taylor, Jane R.
通讯作者：
Taylor, Jane R.