Skin sympathetic nerve activity as a biomarker of fitness.
Skin sympathetic nerve activity as a biomarker of fitness.
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DOI：
10.1016/j.hrthm.2021.08.031
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发表时间：
2021-12
期刊：
影响因子：
5.5
通讯作者：
Everett TH 4th
中科院分区：
文献类型：
--
作者：
Liu X;Kumar A;O'Neil J;Wong J;Saadoon O;Kadire S;Mitscher GA;Li X;Chen PS;Emery MS;Everett TH 4th
运动压力测试经常用于暴露心律失常。有氧运动调节已被用作非药物抗心律失常干预措施。测试以下假设：非侵入性记录的皮肤交感神经活动 (SKNA) 在运动过程中会增加，并且 SKNA 反应会根据健身水平而变化。记录了 39 名接受增量运动测试的患者的耗氧量 (VO2) 和 SKNA。根据年龄、性别和最大摄氧量，将患者分为 5 个健康级别。通过运动，所有患者的 aSKNA（1.58±1.12 μV 至 4.50±3.06 μV，p=0.000）和 HR（87.40±20.42 bmp 至 154.13±16.82 bmp，p=0.000）均显着增加。使用平均 SKNA (aSKNA) 的混合线性模型，其中具有固定效应健身、运动时间、恢复时间以及受试者水平截距、运动时间和恢复时间斜率的随机效应。健康不佳组的平均 SKNA (aSKNA) 显着高于其他组 (p=0.0273)。对于所有研究对象，随着运动的进行，aSKNA 每分钟增加 5%，随着恢复的进行，aSKNA 每分钟减少 15%。健康变量编码有关合并症和体重指数的信息。一旦了解健康水平，合并症和 BMI 与 aSKNA 就没有显着相关性。在所有组中，aSKNA 与 HR（R2=0.47±0.23）和 VO2（R2=0.68±0.25）呈正相关。体能水平决定了运动时SKNA增加的幅度和时间过程。 SKNA 可能是运动压力测试中有用的健身生物标志物。
Exercise stress testing is frequently used to expose cardiac arrhythmias. Aerobic exercise conditioning has been used as a nonpharmacologic antiarrhythmic intervention. To test the hypothesis that non-invasively recorded skin sympathetic nerve activity (SKNA) is increased during exercise and that SKNA response varies according to fitness levels. Oxygen consumption (VO2) and SKNA were recorded in 39 patients undergoing an incremental exercise test. Patients were grouped by 5 levels of fitness based on age, sex and VO2max. With exercise, all patients had a significant increase in aSKNA (1.58±1.12 μV to 4.50±3.06 μV, p=0.000) and HR (87.40±20.42 bmp to 154.13±16.82 bmp, p=0.000). A mixed linear model of average SKNA (aSKNA) was used with fixed effects fitness, exercise time, recovery time and random effects of subject level intercept, slopes for exercise time and recovery times. The Poor fitness group had significantly higher average SKNA (aSKNA) than the others (p=0.0273). For all subjects studied, the aSKNA increased by 5% per min with the progression of exercise and decreased by 15% per min with the progression of recovery. The fitness variable encodes information on both comorbidities and BMI. Once fitness level is known, the comorbidities and BMI are not significantly associated with aSKNA. In all groups, aSKNA positively correlated with HR (R2=0.47±0.23) and VO2 (R2=0.68±0.25). The fitness level determines the magnitude and time course of SKNA increase during exercise. SKNA may be a useful fitness biomarker in exercise stress testing.
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