Deletion Polymorphisms in the Promoter Region of Fcγ Receptor IIB Is Not Associated with Antigen‐Specific IgG2a and IgG2b Antibody Responses in NC/Nga Mice
Deletion Polymorphisms in the Promoter Region of Fcγ Receptor IIB Is Not Associated with Antigen‐Specific IgG2a and IgG2b Antibody Responses in NC/Nga Mice
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Fcγ 受体 IIB 启动子区的缺失多态性与 NC/Nga 小鼠中抗原特异性 IgG2a 和 IgG2b 抗体反应无关
DOI：
10.1111/j.1348-0421.2006.tb03817.x
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发表时间：
2006
影响因子：
2.6
通讯作者：
Shigeru Yamamoto
中科院分区：
文献类型：
--
作者：
T. Sakai;M. Kogiso;Kaori Mitsuya;Tatsushi Komatsu;Shigeru Yamamoto
Fcγ 受体 (R) IIB 是一种 IgG 的低亲和力 FcR，当这两种受体通过含有 Ag 和 IgG 的免疫复合物 (IC) 交联时，会抑制 B 细胞 Ag R (BCR) 介导的激活。我们在人类特应性皮炎模型 NC/Nga 小鼠中发现了 fcgr2b 启动子区域的缺失多态性。 NC/Nga 小鼠产生的卵清蛋白 (OVA) 特异性 IgG、IgG2a 和 IgG2b 水平显着高于 BALB/c 小鼠。对 (BALB/c×NC/Nga)F1×BALB/c 或 (BALB/c×NC/Nga) F1×NC/Nga 回交小鼠的分析表明，NC/Nga 小鼠中 fcgr2b 的缺失多态性并不直接调节超 OVA 特异性 IgG2a 和 IgG2b Ab 反应。
Fcγ receptor (R) IIB, a low‐affinity FcR for IgG, inhibits B cell Ag R (BCR)‐mediated activation when these two receptors are cross‐linked by Ag and IgG‐containing immune complexs (ICs). We found deletion polymorphisms in the promoter region of fcgr2b in NC/Nga mice, a model for human atopic dermatitis. NC/Nga mice produced significantly higher levels of ovalbumin (OVA)‐specific IgG, IgG2a and IgG2b than did BALB/c mice. Analysis of (BALB/c×NC/Nga)F1×BALB/c or (BALB/c×NC/Nga) F1×NC/Nga backcross mice revealed that deletion polymorphisms of fcgr2b in NC/Nga mice does not directly regulate hyper OVA‐specific IgG2a and IgG2b Ab responses.
影响因子：
56.9
作者：
HUANG, S;HENDRIKS, W;AGUET, M
通讯作者：
AGUET, M