Schizophrenia Past Clozapine: What Works?
Schizophrenia Past Clozapine: What Works?
复制标题
氯氮平治疗精神分裂症：什么有效？
DOI：
10.1097/jcp.0b013e31827a813b
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发表时间：
2013
影响因子：
2.9
通讯作者：
F. Mustafa
中科院分区：
文献类型：
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作者：
F. Mustafa
摘要 氯氮平治疗难治性精神分裂症优于其他抗精神病药物。然而，其使用因其潜在的严重副作用而受到限制。对于因缺乏反应、不耐受或不依从等原因而停用氯氮平的患者的管理指导很少。检索文献以查找有关替代氯氮平的抗精神病药物对此类患者的疗效的研究。检索发现了 15 篇论文，本文对这些论文进行了评估。奥氮平是经过最多测试的氯氮平替代品，大多数研究报告了积极的结果，特别是对于病情较轻的患者和因反应不佳以外的原因停止使用氯氮平的患者。其他抗精神病药物没有以这种方式进行充分测试。我们的结论是，对于停用氯氮平的患者，考虑尝试奥氮平是值得的。
Abstract Clozapine is superior to other antipsychotic drugs for treatment of refractory schizophrenia. However, its use has been limited by its potentially serious adverse effects. There is little guidance on the management of patients who discontinue clozapine for reasons such as lack of response, intolerance, or noncompliance. The literature was searched for studies on the efficacy of antipsychotics that replaced clozapine in such patients. The search revealed 15 papers, which were evaluated in this article. Olanzapine was the most tested alternative to clozapine with most of the studies reporting positive outcome, especially in patients with less severe illness and those who stop clozapine for reasons other than poor response. Other antipsychotics were not adequately tested in this manner. We concluded that in patients who discontinue clozapine, considering a trial of olanzapine would be worthwhile.
影响因子：
--
作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
通讯作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
地西泮治疗精神分裂症恶化的早期症状。
DOI：
10.1176/ajp.156.2.299
发表时间：
1999
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
CarpenterJr,WT;Buchanan,RW;Kirkpatrick,B;Breier,AF
通讯作者：
Breier,AF