Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats.
Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats.
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DOI：
10.1007/s00213-012-2683-3
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发表时间：
2012-07
影响因子：
3.4
通讯作者：
Yang, Chae Ha
中科院分区：
文献类型：
--
作者：
Yoon, Seong Shoon;Yang, Eun Jin;Lee, Bong Hyo;Jang, Eun Young;Kim, Hee Young;Choi, Sun-Mi;Steffensen, Scott C.;Yang, Chae Ha
可卡因成瘾与高复发率有关，压力已被确定为主要风险因素。我们以前已经证明，针灸减少药物自我管理和多巴胺释放的神经核（NAc），一个大脑结构牵连在压力诱导的恢复寻求药物的行为。本研究旨在探讨针刺对足电击诱发的可卡因觅药恢复的影响，以及在应激诱发的可卡因觅药恢复条件下，NAc中c-Fos和转录因子cAMP反应元件结合蛋白（CREB）表达的影响。训练雄性Sprague-Dawley大鼠自我给予可卡因（1.0 mg/kg）14天，然后进行消退，然后进行足电击应激。足电击应激后针刺双侧神门穴1 min。急性足电击应激恢复可卡因寻求行为，并增强c-Fos表达和磷酸化CREB（pCREB）在可卡因预暴露大鼠的NAc壳激活。另一方面，针刺HT 7而不是对照点（LI 5），显著降低了NAc壳中可卡因寻求的恢复（与对照值相比，抑制率为86.5%）、c-Fos表达（抑制率为81.7%）和pCREB活化（抑制率为79.3%）。这些结果表明，针刺通过调节NAc壳中的神经元激活来减弱应激诱导的复发。
Cocaine addiction is associated with high rates of relapse, and stress has been identified as a major risk factor. We have previously demonstrated that acupuncture reduces drug self-administration and dopamine release in the nucleus accumbens (NAc), a brain structure implicated in stress-induced reinstatement of drug-seeking behavior. This study was conducted to investigate the effects of acupuncture on footshock-induced reinstatement of cocaine-seeking and the expression of c-Fos and the transcription factor cAMP response element-binding protein (CREB) in the NAc, used as markers of neuronal activation in conditions of stress-induced reinstatement to cocaine. Male Sprague–Dawley rats were trained to self-administer cocaine (1.0 mg/kg) for 14 days, followed by extinction and then footshock stress. Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min after footshock stress. Acute footshock stress reinstated cocaine-seeking behavior and enhanced c-Fos expression and phosphorylated CREB (pCREB) activation in the NAc shell in cocaine pre-exposed rats. On the other hand, acupuncture at HT7, but not at control point (LI5), markedly reduced reinstatement of cocaine-seeking (86.5 % inhibition vs. control value), c-Fos expression (81.7% inhibition), and pCREB activation (79.3% inhibition) in the NAc shell. These results suggest that acupuncture attenuates stress-induced relapse by regulating neuronal activation in the NAc shell.
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影响因子：
3.3
作者：
Funk, D;Li, Z;Lê, AD
通讯作者：
Lê, AD
DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
3.3
作者：
FINLAY, JM;ZIGMOND, MJ;ABERCROMBIE, ED
通讯作者：
ABERCROMBIE, ED
影响因子：
5
作者：
Giardino, L;Zanni, M;Covelli, V
通讯作者：
Covelli, V
影响因子：
3.4
作者：
Campbell, UC;Lac, ST;Carroll, ME
通讯作者：
Carroll, ME