Laws of physics help explain capillary non-perfusion in diabetic retinopathy
Laws of physics help explain capillary non-perfusion in diabetic retinopathy
复制标题
物理定律有助于解释糖尿病视网膜病变中的毛细血管无灌注
作者：
E. Stefánsson;Y. Chan;T. Bek;S. Hardarson;D. Wong;D. Wilson
目的是利用物理定律来阐明糖尿病视网膜病变中毛细血管无灌注的机制。在糖尿病视网膜病变中，周细胞的损失削弱毛细血管壁和血管扩张。扩张的毛细血管具有降低的流动阻力，因此增加了该血管中的流量，并减少了相邻毛细血管中的流量。因此，从扩张的毛细血管形成优先的分流血管，并且相邻的毛细血管变得非灌注。我们应用拉普拉斯和哈根-普瓦莱定律来更好地理解导致毛细血管非灌注的现象。这些物理定律可以为进一步阐明这一研究领域的物理或数学模型提供基础。拉普拉斯定律预测，假设跨壁压恒定，较弱的血管壁将扩张。Hagen-Poiffille流量方程和Ostwald-de Waele粘度关系预测扩张血管将接收比相邻毛细血管更高的流体流量部分。在扩张的血管中，粘度将降低，进一步失衡，并导致在扩张的“优先”分流血管旁边出现一片未灌注的毛细血管。物理原理支持或启发新的假说来解释眼科学中知之甚少的现象。Cogan和Kuwabara首先提出的周细胞死亡和毛细血管重塑的理论，已经与糖尿病视网膜病变的组织学和血管造影观察结果相一致。我们已经证明，它也支持经典物理定律。
The purpose is to use laws of physics to elucidate the mechanisms behind capillary non-perfusion in diabetic retinopathy. In diabetic retinopathy, loss of pericytes weakens capillary walls and the vessel dilates. A dilated capillary has reduced resistance to flow, therefore increased flow in that vessel and decreased in adjoining capillaries. A preferential shunt vessel is thus formed from the dilated capillary and the adjacent capillaries become non-perfused. We apply the laws of Laplace and Hagen-Poiseuille to better understand the phenomena that lead to capillary non-perfusion. These laws of physics can give a foundation for physical or mathematical models to further elucidate this field of study. The law of Laplace predicts that a weaker vessel wall will dilate, assuming constant transmural pressure. The Hagen-Poiseuille equation for flow and the Ostwald-de Waele relationship for viscosity predict that a dilated vessel will receive a higher portion of the fluid flow than the adjoining capillaries. Viscosity will decrease in the dilated vessel, furthering the imbalance and resulting in a patch of non-perfused capillaries next to the dilated 'preferential' shunt vessel. Physical principles support or inspire novel hypotheses to explain poorly understood phenomena in ophthalmology. This thesis of pericyte death and capillary remodelling, which was first proposed by Cogan and Kuwabara, already agrees with histological and angiographical observations in diabetic retinopathy. We have shown that it is also supported by classical laws of physics.
影响因子：
7.7
作者：
Kim, SY;Johnson, MA;Lutty, GA
通讯作者：
Lutty, GA