Rotation of the central pair microtubules in eukaryotic flagella.
Rotation of the central pair microtubules in eukaryotic flagella.
复制标题
真核鞭毛中央微管对的旋转。
DOI：
--
复制
发表时间：
1999
影响因子：
3.3
通讯作者：
G. Witman
中科院分区：
文献类型：
--
作者：
C. Omoto;I. Gibbons;Ritsu Kamiya;C. Shingyoji;Keiichi Takahashi;G. Witman
真核生物鞭毛中的中心对旋转现象被报道已有20年了（Omoto和Kung，1979）。当时，提出了一个模型，其中中央对作为分配器的功能，以调节动力蛋白的活动之间的外部双重微管。从那时起获得的视频证据和本文收集的证据与这一模型一致。几何参数表明，必须有周向和纵向调节的剪切力产生有效的轴丝弯曲运动。中央对微管是理想的位置，以执行这一调节功能。中央对滑动的外部双联体的调节，以及后者的旋转，可以解释在使用相同的基本9 + 2结构的生物体中发现的二维和三维鞭毛和纤毛波形的广泛多样性。
It has been 20 years since the phenomenon of central pair rotation in eukaryotic flagella was reported (Omoto, and Kung, 1979 ). At that time, a model was proposed in which the central pair functions as a distributor to regulate dynein activity among the outer doublet microtubules. The video evidence obtained since then and gathered together in this essay is consistent with this model. Geometric arguments indicate that there must be circumferential and longitudinal regulation of shear forces to produce effective bending motion of an axoneme. Central pair microtubules are ideally situated to perform this regulatory function. The regulation of outer doublet sliding by the central pair, together with the rotation of the latter, where this occurs, may explain the wide diversity of two- and three-dimensional flagellar and ciliary waveforms that is found in organisms using the same basic 9 + 2 structure.
低 ATP 条件下的重新激活可区分不同类别的麻痹鞭毛突变体。
影响因子：
--
作者：
Frey,E;Brokaw,CJ;Omoto,CK
通讯作者：
Omoto,CK