Molecular mechanisms of epithelial-mesenchymal transition.
Molecular mechanisms of epithelial-mesenchymal transition.
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DOI：
10.1038/nrm3758
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发表时间：
2014-03
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--
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上皮细胞转分化为能动的间充质细胞（称为上皮-间充质转化（EMT）的过程）在发育、伤口愈合和干细胞行为中是不可或缺的，并且在病理上有助于纤维化和癌症进展。细胞分化和行为的这种转换是由关键转录因子介导的，包括SNAIL、锌指E盒结合（ZEB）和碱性螺旋-环-螺旋转录因子，其功能在转录、翻译和翻译后水平上受到精细调控。EMT期间基因表达的重编程以及非转录变化由响应细胞外信号的信号通路启动和控制。其中，转化生长因子-β（TGFβ）家族信号传导具有主导作用;然而，信号传导途径的会聚对于EMT是必不可少的。
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial–mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels. The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues. Among these, transforming growth factor-β (TGFβ) family signalling has a predominant role; however, the convergence of signalling pathways is essential for EMT.
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影响因子：
2.8
作者：
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