Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention.
Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention.
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DOI：
10.2174/18715206113139990119
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发表时间：
2013-09
影响因子：
2.8
通讯作者：
Pelling JC
中科院分区：
文献类型：
--
作者：
Tong X;Pelling JC
天然产品是抗癌铅分子的重要来源，大量食用水果和蔬菜与降低某些癌症的风险有关。许多努力已经投入到鉴定和开发植物性膳食成分作为化学预防剂。其中，芹菜素是一种天然存在的类黄酮，存在于各种水果和叶类蔬菜中，已被证明具有显著的抗氧化、抗炎和抗癌特性。本文综述了芹菜素在细胞和分子水平上的抗癌和化学预防作用，其化学结构和性质，重点讨论了芹菜素抑制PI3K/Akt/mTOR信号通路的相关机制。
Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.
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影响因子：
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