Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia.
Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia.
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DOI：
10.1080/22221751.2023.2244091
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发表时间：
2023-12
影响因子：
13.2
通讯作者：
中科院分区：
文献类型：
--
作者：
高致病性禽流感（HPAI）H5 N1是A型流感病毒的一个亚型，主要在鸟类中发现。该亚型于1996年在中国出现，并在全球范围内传播，导致鸟类和人类的严重发病率和死亡率。在柬埔寨，2023年2月报告了一例涉及一名11岁女孩的致命病例，标志着该国自2014年以来首次出现人类HPAI H5 N1感染。本研究通过评估人H5 N1分离株A/Cambodia/NPH 230032/2023（KHM/23）的受体结合、融合pH值、HA热稳定性和抗原性，检查了其人畜共患潜力。结果表明，KHM/23与早期进化枝2.3.2.1c HPAI H5 N1毒株具有相似的受体结合和抗原性，并且不与类人受体结合。尽管显示出有限的人畜共患病风险，但KHM/23中融合物的热稳定性增加和pH值降低表明对家禽的潜在威胁，强调需要警惕监测。
High pathogenicity avian influenza (HPAI) H5N1 is a subtype of the influenza A virus primarily found in birds. The subtype emerged in China in 1996 and has spread globally, causing significant morbidity and mortality in birds and humans. In Cambodia, a lethal case was reported in February 2023 involving an 11-year-old girl, marking the first human HPAI H5N1 infection in the country since 2014. This research examined the zoonotic potential of the human H5N1 isolate, A/Cambodia/NPH230032/2023 (KHM/23), by assessing its receptor binding, fusion pH, HA thermal stability, and antigenicity. Results showed that KHM/23 exhibits similar receptor binding and antigenicity as the early clade 2.3.2.1c HPAI H5N1 strain, and it does not bind to human-like receptors. Despite showing limited zoonotic risk, the increased thermal stability and reduced pH of fusion in KHM/23 indicate a potential threat to poultry, emphasizing the need for vigilant monitoring.
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影响因子：
5.4
作者：
Reed, Mark L.;Bridges, Olga A.;Russell, Charles J.
通讯作者：
Russell, Charles J.
影响因子：
64.8
作者：
Imai, Masaki;Watanabe, Tokiko;Hatta, Masato;Das, Subash C.;Ozawa, Makoto;Shinya, Kyoko;Zhong, Gongxun;Hanson, Anthony;Katsura, Hiroaki;Watanabe, Shinji;Li, Chengjun;Kawakami, Eiryo;Yamada, Shinya;Kiso, Maki;Suzuki, Yasuo;Maher, Eileen A.;Neumann, Gabriele;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
DOI：
10.1126/science.1213362
发表时间：
2012-06-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Herfst S;Schrauwen EJ;Linster M;Chutinimitkul S;de Wit E;Munster VJ;Sorrell EM;Bestebroer TM;Burke DF;Smith DJ;Rimmelzwaan GF;Osterhaus AD;Fouchier RA
通讯作者：
Fouchier RA
影响因子：
13.2
作者：
Peacock TP;Benton DJ;Sadeyen JR;Chang P;Sealy JE;Bryant JE;Martin SR;Shelton H;McCauley JW;Barclay WS;Iqbal M
通讯作者：
Iqbal M
影响因子：
3.7
作者：
Xu, XY;Subbarao, K;Guo, YJ
通讯作者：
Guo, YJ