Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases.
Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases.
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DOI：
10.1007/978-90-481-8622-8_13
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发表时间：
2010
影响因子：
--
通讯作者：
Su, Tsung-Ping
中科院分区：
文献类型：
--
作者：
Hayashi, Teruo;Su, Tsung-Ping
尽管有大量数据阐明了胆固醇在质膜脂筏中的作用，但胆固醇和相关脂质在亚细胞膜水平的脂筏微区（例如内质网（ER）膜）中的作用仍然知之甚少。然而，越来越多的证据开始揭示胆固醇和脂质在内质网膜脂筏上的重要性。在 ER 膜的脂筏样微域中鉴定出了一些 ER 蛋白，包括 sigma-1 受体伴侣。 sigma-1 受体在直接与线粒体相连的 ER 膜子域中高度表达，被称为线粒体相关 ER 膜或 MAM，已被证明与类固醇和胆固醇相关。 sigma-1 受体与 ER 脂质代谢/运输、质膜脂筏重建、营养因子信号传导、细胞分化和针对 β-淀粉样蛋白诱导的神经毒性的细胞保护有关。最近对 sigma-1 受体伴侣和其他 ER 蛋白的研究清楚地表明，胆固醇与这些 ER 蛋白协同作用，可能调节 ER 的几个重要功能，包括 ER 蛋白的折叠、降解、区室化和分离，以及鞘脂的生物合成。
Despite substantial data elucidating the roles of cholesterol in lipid rafts at the plasma membrane, the roles of cholesterol and related lipids in lipid raft microdomains at the level of subcellular membrane, such as the endoplasmic reticulum (ER) membrane, remain less understood. Growing evidence, however, begins to unveil the importance of cholesterol and lipids on the lipid raft at the ER membrane. A few ER proteins including the sigma-1 receptor chaperone were identified at lipid raft-like microdomains of the ER membrane. The sigma-1 receptor, which is highly expressed at a subdomain of ER membrane directly apposing mitochondria and known as the mitochondria-associated ER membrane or MAM, has been shown to associate with steroids as well as cholesterol. The sigma-1 receptor has been implicated in ER lipid metabolisms/transports, lipid raft reconstitution at the plasma membrane, trophic factor signalling, cellular differentiation, and cellular protection against β-amyloid-induced neurotoxicity. Recent studies on sigma-1 receptor chaperones and other ER proteins clearly suggest that cholesterol, in concert with those ER proteins, may regulate several important functions of the ER including folding, degradation, compartmentalization, and segregation of ER proteins, and the biosynthesis of sphingolipids.
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DOI：
10.1126/science.1166127
发表时间：
2009-02-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fontanilla D;Johannessen M;Hajipour AR;Cozzi NV;Jackson MB;Ruoho AE
通讯作者：
Ruoho AE
影响因子：
4.4
作者：
Dun, Ying;Thangaraju, Muthusamy;Smith, Sylvia B.
通讯作者：
Smith, Sylvia B.
DOI：
10.1073/pnas.0402890101
发表时间：
2004-10-12
影响因子：
11.1
作者：
Hayashi, T;Su, TP
通讯作者：
Su, TP
DOI：
10.1073/pnas.93.15.8072
发表时间：
1996-07-23
影响因子：
11.1
作者：
Hanner, M;Moebius, FF;Glossmann, H
通讯作者：
Glossmann, H
影响因子：
6.1
作者：
Hayashi, T;Su, TP
通讯作者：
Su, TP