Mining CK2 in cancer.
Mining CK2 in cancer.
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DOI：
10.1371/journal.pone.0115609
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Dominguez I
中科院分区：
文献类型：
--
作者：
Ortega CE;Seidner Y;Dominguez I
癌症是世界范围内的主要死亡原因。癌细胞不受控制地增殖，并且在许多情况下扩散到身体的其他部位。历史上参与癌症的蛋白质是蛋白激酶CK 2。CK 2是一种丝氨酸-苏氨酸激酶，参与细胞生长、细胞增殖和细胞凋亡。当在小鼠组织中过度表达时，CK 2作为癌基因发挥作用，并且可以与已知的癌基因如ras协同作用，以诱导培养细胞中的细胞转化。CK 2，通常是CK 2 α蛋白，在许多人类肿瘤中发现升高。然而，我们对CK 2 α'和CK 2 β蛋白的信息很少，并且对CK 2基因转录表达的信息也很少。在这里，我们使用Oncomine数据库在美国死亡率最高的六种癌症中探索原发性肿瘤组织中CK 2转录物的表达。此外，我们使用Kaplan-Meier Plotter数据库在乳腺癌、卵巢癌和肺癌中研究了CK 2表达与总生存率之间的相关性。我们发现在原发肿瘤组织中CK 2基因的表达普遍上调。然而，我们发现在一些肿瘤中CK 2 α'转录本表达不足，在一些侵袭性肿瘤中CK 2 β转录本表达增加，在一些肿瘤前体中CK 2转录本表达失调。CK 2表达水平与患者生存率也有相关性。这些数据为CK 2作为癌症研究的生物标志物和癌症治疗的靶点提供了额外的证据。
Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and, many cases, spread to other parts of the body. A protein historically involved in cancer is protein kinase CK2. CK2 is a serine-threonine kinase that has been involved in cell growth, cell proliferation and cell apoptosis. CK2 functions as an oncogene when overexpressed in mouse tissues, and can synergize with known oncogenes, such as ras, to induce cell transformation in cells in culture. CK2, typically the CK2α protein, is found elevated in a number of human tumors. However, we have little information on CK2α' and CK2β proteins, and scarce information on CK2 gene transcript expression. Here, we explore the expression of CK2 transcripts in primary tumor tissues using the database Oncomine in the six cancers with the highest mortality in the U.S.A. In addition, we studied the correlation between CK2 expression and overall survival using the Kaplan-Meier Plotter database in breast, ovarian, and lung cancers. We found widespread upregulation in the expression of CK2 genes in primary tumor tissues. However, we found underexpression of CK2α' transcripts in some tumors, increased CK2β transcripts in some invasive tumors, and deregulation of CK2 transcripts in some tumor precursors. There was also correlation between CK2 expression levels and patient survival. These data provides additional evidence for CK2 as a biomarker for cancer studies and as a target for cancer therapy.
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影响因子：
8
作者：
Dominguez, I.;Sonenshein, G. E.;Seldin, D. C.
通讯作者：
Seldin, D. C.
影响因子：
4.4
作者：
Axtell, Robert C.;Xu, Liang;Raman, Chander
通讯作者：
Raman, Chander
影响因子：
5.7
作者：
GAPANY, M;FAUST, RA;AHMED, K
通讯作者：
AHMED, K
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
82.9
作者：
Beer, DG;Kardia, SLR;Hanash, S
通讯作者：
Hanash, S