Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak.
Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak.
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白介素6作为Covid-19的严重过程的预测因素的作用：在Covid-19爆发期间长期护理机构的患者的回顾性数据分析。
DOI：
10.1186/s12879-021-05945-8
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发表时间：
2021-03-29
影响因子：
3.7
通讯作者：
Kušnírová A
中科院分区：
文献类型：
--
作者：
Sabaka P;Koščálová A;Straka I;Hodosy J;Lipták R;Kmotorková B;Kachlíková M;Kušnírová A
Covid-19 是一种在长期护理机构 (LTCF) 的老年居民中发病率和死亡率较高的疾病。在 LTCF 爆发 SARS-CoV-2 感染期间，有效的筛查工具对于识别有重症风险的患者至关重要。我们在斯洛伐克的一个 LTCF 中探讨了白细胞介素 6 (IL-6) 在 Covid-19 爆发期间作为严重疾病预测因子的作用。我们对 2020 年 4 月 11 日至 2020 年 5 月 5 日期间在斯洛伐克的一个 LTCF 爆发期间诊断出的 COVID-19 病例进行了回顾性数据分析。在诊断出 Covid-19 后的 24 小时内，在 LTCF 中进行了临床和实验室筛查，以确定需要住院治疗的患者。血氧饱和度低于90%的患者立即被送往医院。每天对住在 LFTC 的患者进行监测，出现低氧血症的患者被转移到医院。我们分析了初始评估时的 IL-6 与随访期间低氧血症发生之间的关联，并确定了能够预测需要氧疗的低氧血症发生的 IL-6 截止值。分析中纳入了 53 名确诊为 Covid-19 的患者（11 名男性，42 名女性）。 19 名（53%）患者在患病期间出现低氧血症。低氧血症患者在初筛时的IL-6、C反应蛋白、降钙素原、纤维蛋白原、总胆红素、天冬氨酸转氨酶和丙氨酸转氨酶浓度显着升高。 ROC 分析确定 IL-6 是低氧血症最有力的预测因子。 IL-6浓度>24pg/mL预测低氧血症的发生的敏感性为100%，特异性为88.9%。阳性预测值为76.9%，阴性预测值为100%。初始评估时 IL-6 的浓度> 24 pg/mL 可以预测需要住院治疗的低氧血症的发生，具有出色的敏感性和良好的特异性。 IL-6 似乎是严重 Covid-19 发展的潜在预测因子，可能有助于早期识别需要住院治疗的患者。需要进一步的研究来评估使用 IL-6 作为 Covid-19 严重病程的有效筛查工具的稳健性。在线版本包含可在 10.1186/s12879-021-05945-8 获取的补充材料。
Covid-19 is a disease with high morbidity and mortality among elderly residents of long-term care facilities (LTCF). During an outbreak of SARS-CoV-2 infection in the LTCF an effective screening tool is essential to identify the patients at risk for severe disease. We explored the role of interleukin 6 (IL-6) as a predictor for severe disease during the outbreak of Covid-19 in one LTCF in Slovakia. We conducted a retrospective data analysis of cases of COVID-19, diagnosed during the outbreak in one LTCF in Slovakia between April 11, 2020, and May 5, 2020. Within 24 h after the diagnosis of Covid-19, clinical and laboratory screening was performed in the LTCF to identify patients in need of hospitalization. Patients with oxygen saturation below 90% were immediately referred to the hospital. Patients staying in the LFTC were monitored daily and those that developed hypoxemia were transferred to the hospital. We analyzed the association between the IL-6 at the initial assessment and development of hypoxemia during follow up and determined the cut-off of the IL-6 able to predict the development of hypoxemia requiring oxygen therapy. Fifty-three patients (11 men, 42 women) with diagnosed Covid-19 were included in the analysis. 19 (53%) patients developed hypoxemia during the disease. Patients with hypoxemia had significantly higher concentrations of IL-6, C-reactive protein, procalcitonin, fibrinogen, total bilirubin, aspartate aminotransferase and alanine aminotransferase at initial screening. ROC analyses identified IL-6 as the most robust predictor of hypoxemia. The concentration of IL-6 > 24 pg/mL predicted the development of hypoxemia with the sensitivity of 100% and specificity of 88.9%. The positive and negative predictive values were 76.9, and 100% respectively. The concentration of IL-6 > 24 pg/mL at initial assessment predicted the development of hypoxemia requiring hospitalization with excellent sensitivity and good specificity. IL-6 appears as a potential predictor for the development of the severe Covid-19 and might serve for early identification of patients in need of hospitalization. Further studies are needed to evaluate the robustness of the use of IL-6 as an effective screening tool for the severe course of Covid-19. The online version contains supplementary material available at 10.1186/s12879-021-05945-8.
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影响因子：
25.4
作者：
Guaraldi, Giovanni;Meschiari, Marianna;Mussini, Cristina
通讯作者：
Mussini, Cristina
影响因子：
--
作者：
Magro, Giuseppe
通讯作者：
Magro, Giuseppe
DOI：
10.2807/1560-7917.es.2020.25.12.2000256
发表时间：
2020-03-01
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Russell, Timothy W;Hellewell, Joel;Kucharski, Adam J
通讯作者：
Kucharski, Adam J
影响因子：
3.8
作者：
Mandel, Mathilda;Harari, Gil;Achiron, Anat
通讯作者：
Achiron, Anat
影响因子：
158.5
作者：
McMichael, Temet M.;Currie, Dustin W.;Duchin, Jeffrey S.
通讯作者：
Duchin, Jeffrey S.