A mesoscale connectome of the mouse brain.
A mesoscale connectome of the mouse brain.
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对大脑的接线图的全面知识是理解神经系统在局部和全球尺度上如何处理信息的基础我们报告了小鼠的大脑，细胞级，中尺度连接组。腺相关的病毒载体从定义的区域和细胞类型中追踪轴突项目，以及高通量的串行两光子断层扫描，以对EGFP标记的轴突进行成像。三维（3D）参考空间，导致全脑连接矩阵。其他网络属性。支持健康和疾病中的行为和认知过程。
Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding how the nervous system processes information at both local and global scales. However, with the singular exception of the C. elegans microscale connectome, there are no complete connectivity data sets in other species. Here we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain. This systematic and standardized approach allows spatial registration of individual experiments into a common three dimensional (3D) reference space, resulting in a whole-brain connectivity matrix. A computational model yields insights into connectional strength distribution, symmetry and other network properties. Virtual tractography illustrates 3D topography among interconnected regions. Cortico-thalamic pathway analysis demonstrates segregation and integration of parallel pathways. The Allen Mouse Brain Connectivity Atlas is a freely available, foundational resource for structural and functional investigations into the neural circuits that support behavioural and cognitive processes in health and disease.
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影响因子：
5.3
作者：
Bokor, Hajnalka;Acsady, Laszlo;Deschenes, Martin
通讯作者：
Deschenes, Martin
影响因子：
64.8
作者：
Bock, Davi D.;Lee, Wei-Chung Allen;Kerlin, Aaron M.;Andermann, Mark L.;Hood, Greg;Wetzel, Arthur W.;Yurgenson, Sergey;Soucy, Edward R.;Kim, Hyon Suk;Reid, R. Clay
通讯作者：
Reid, R. Clay
影响因子：
2.5
作者：
BECKSTEAD, RM
通讯作者：
BECKSTEAD, RM
影响因子：
2.5
作者：
CECHETTO, DF;SAPER, CB
通讯作者：
SAPER, CB
影响因子：
9.2
作者：
Chiang, Ann-Shyn;Lin, Chih-Yung;Hwang, Jenn-Kang
通讯作者：
Hwang, Jenn-Kang