The amazing osteocyte.
The amazing osteocyte.
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DOI：
10.1002/jbmr.320
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发表时间：
2011-02
影响因子：
6.2
通讯作者：
Bonewald, Lynda F.
中科院分区：
文献类型：
--
作者：
Bonewald, Lynda F.
近十年来，关于骨细胞的分子生物学和功能的数据爆炸式增长。这种细胞远不是“骨中的被动占位物”，而是被发现具有许多功能，例如通过调节破骨细胞和成骨细胞活性来充当骨重塑的协调者，并且还充当内分泌细胞。骨细胞是可溶性因子的来源，不仅靶向骨表面上的细胞，而且靶向远处器官，如肾脏、肌肉和其他组织。该细胞在磷酸盐代谢和钙可用性中起作用，并且可以重塑其骨间隙基质。骨细胞占成人骨中所有骨细胞的90%至95%，并且是寿命最长的骨细胞，在其矿化环境中长达数十年。随着年龄的增长，这些细胞死亡，留下空洞，经常微晶化。在老化骨如骨坏死骨中，空骨陷窝与重建减少相关。用于治疗炎性疾病的炎症因子如肿瘤坏死因子和糖皮质激素诱导骨细胞死亡，但通过不同的机制具有潜在的不同结果。因此，健康、有活力的骨细胞对于骨和其他器官的正常功能是必要的。© 2011美国骨与矿物质研究学会。
The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell. The osteocyte is a source of soluble factors not only to target cells on the bone surface but also to target distant organs, such as kidney, muscle, and other tissues. This cell plays a role in both phosphate metabolism and calcium availability and can remodel its perilacunar matrix. Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment. As we age, these cells die, leaving behind empty lacunae that frequently micropetrose. In aged bone such as osteonecrotic bone, empty lacunae are associated with reduced remodeling. Inflammatory factors such as tumor necrosis factor and glucocorticoids used to treat inflammatory disease induce osteocyte cell death, but by different mechanisms with potentially different outcomes. Therefore, healthy, viable osteocytes are necessary for proper functionality of bone and other organs. © 2011 American Society for Bone and Mineral Research.
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影响因子：
3.3
作者：
Cherian, PP;Siller-Jackson, AJ;Jiang, JX
通讯作者：
Jiang, JX
影响因子：
3
作者：
Gluhak-Heinrich, J.;Pavlin, D.;Harris, S. E.
通讯作者：
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DOI：
10.1073/pnas.1009382107
发表时间：
2010-08-03
影响因子：
11.1
作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Schaffler, M. B.