Obesity gene NEGR1 associated with white matter integrity in healthy young adults.
Obesity gene NEGR1 associated with white matter integrity in healthy young adults.
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DOI：
10.1016/j.neuroimage.2014.07.041
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发表时间：
2014-11-15
期刊：
影响因子：
5.7
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Dennis EL;Jahanshad N;Braskie MN;Warstadt NM;Hibar DP;Kohannim O;Nir TM;McMahon KL;de Zubicaray GI;Montgomery GW;Martin NG;Toga AW;Wright MJ;Thompson PM
肥胖是发达国家的一个关键公共卫生问题，随着年龄的增长，它会对心血管和大脑健康产生影响。许多常见的遗传变异与肥胖有关。在这里，我们的目标是了解肥胖相关基因的变体-NEGR 1，FTO，MTCH 2，MC 4 R，LRRN 6C，MAP 2K 5，FAIM 2，SEC 16 B，ETV 5，BDNF-AS，ATXN 2L，ATP 2A 1，KCTD 15和TNN 13 K-是否与白色微结构特性相关，通过昆士兰州双生子成像研究（QTIM）中20-30岁的年轻健康成人的高角分辨率弥散成像（HARDI）进行评估。我们从一个多位点的方法开始，在单核苷酸多态性（SNP）水平上测试一些常见的肥胖遗传风险因素如何共同影响整个大脑的白色物质完整性，并发现了广泛的遗传效应。NEGR 1中的风险等位基因rs 2815752与大脑大部分区域的较低白色物质完整性最相关。在双侧后放射冠的显著区域，风险等位基因的每一个额外拷贝与平均FA降低2.2%相关。这是第一项发现肥胖风险基因与白色物质完整性差异之间存在关联的研究。由于我们的受试者年轻健康，我们的结果表明NEGR 1对大脑结构的影响与其对肥胖的影响无关。
Obesity is a crucial public health issue in developed countries, with implications for cardiovascular and brain health as we age. A number of commonly-carried genetic variants are associated with obesity. Here we aim to see whether variants in obesity-associated genes - NEGR1, FTO, MTCH2, MC4R, LRRN6C, MAP2K5, FAIM2, SEC16B, ETV5, BDNF-AS, ATXN2L, ATP2A1, KCTD15, and TNN13K - are associated with white matter microstructural properties, assessed by high angular resolution diffusion imaging (HARDI) in young healthy adults between 20–30 years of age from the Queensland Twin Imaging study (QTIM). We began with a multi-locus approach testing how a number of common genetic risk factors for obesity at the single nucleotide polymorphism (SNP) level may jointly influence white matter integrity throughout the brain and found a wide spread genetic effect. Risk allele rs2815752 in NEGR1 was most associated with lower white matter integrity across a substantial portion of the brain. Across the area of significance in the bilateral posterior corona radiata, each additional copy of the risk allele was associated with a 2.2% lower average FA. This is the first study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
5.7
作者：
Jahanshad, Neda;Kochunov, Peter V.;Sprooten, Emma;Mandl, Rene C.;Nichols, Thomas E.;Almasy, Laura;Blangero, John;Brouwer, Rachel M.;Curran, Joanne E.;de Zubicaray, Greig I.;Duggirala, Ravi;Fox, Peter T.;Hong, L. Elliot;Landman, Bennett A.;Martin, Nicholas G.;McMahon, Katie L.;Medland, Sarah E.;Mitchell, Braxton D.;Olvera, Rene L.;Peterson, Charles P.;Starr, John M.;Sussmann, Jessika E.;Toga, Arthur W.;Wardlaw, Joanna M.;Wright, Margaret J.;Pol, Hilleke E. Hulshoff;Bastin, Mark E.;McIntosh, Andrew M.;Deary, Ian J.;Thompson, Paul M.;Glahn, David C.
通讯作者：
Glahn, David C.
影响因子：
7.6
作者：
Kohannim, Omid;Jahanshad, Neda;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
5.8
作者：
Haltia, Lauri T.;Viljanen, Antti;Kaasinen, Valtteri
通讯作者：
Kaasinen, Valtteri
DOI：
10.1523/jneurosci.5794-10.2011
发表时间：
2011-05-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Braskie MN;Jahanshad N;Stein JL;Barysheva M;McMahon KL;de Zubicaray GI;Martin NG;Wright MJ;Ringman JM;Toga AW;Thompson PM
通讯作者：
Thompson PM