Multiple functions of phosphoinositide-3 kinase enhancer (PIKE).
Multiple functions of phosphoinositide-3 kinase enhancer (PIKE).
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DOI：
10.1100/tsw.2010.64
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发表时间：
2010-04-13
影响因子：
--
通讯作者：
Ye K
中科院分区：
文献类型：
--
作者：
Chan CB;Ye K
GTP结合蛋白是许多细胞功能的分子开关，包括迁移、增殖和分化。在过去的10年中，我们已经确定了一类新的GTP酶称为磷酸肌醇-3激酶增强子（PIKE），与PI 3 K/Akt相互作用。在神经元中，PIKE通过将各种受体（如mGluR 1和Unc 5 H2）连接到PI 3 K级联来参与针对神经兴奋性毒性损伤的保护机制。有趣的是，PIKE基因（CENTG 1）也在多种人类癌症中扩增，并增强Akt活性，导致其对细胞凋亡和侵袭的抵抗。PIKE还参与了核内体的形成和核蛋白的积累。因此，PIKE具有众多的生物学功能，而不仅仅是作为一种凋亡抑制剂。在这篇综述中，我们将更新我们目前的知识，在各种细胞活动的PIKE的作用。此外，在PIKE基因敲除小鼠中的独特表型所揭示的PIKE在外周组织中的功能也将被讨论。
GTP-binding proteins are the molecular switches of numerous cellular functions, including migration, proliferation, and differentiation. In the past 10 years, we have characterized a novel class of GTPases called phosphoinositide-3 kinase enhancer (PIKE) that interacts with PI3K/Akt. In neurons, PIKE is involved in the protective mechanisms against neuroexcitotoxic insults by linking various receptors, such as mGluR1 and Unc5H2, to the PI3K cascade. Interestingly, the PIKE gene (CENTG1) is also amplified in a variety of human cancers and enhances Akt activity, leading to their resistance against apoptosis and invasion. It has also been demonstrated that PIKE is involved in endosome formation and nuclear protein accumulation. Thus, PIKE possesses multitudinous biological functions rather than solely acting as an apoptosis inhibitor. In this review, we will update our current knowledge of the role of PIKE in various cellular activities. Moreover, the functions of PIKE in peripheral tissues as revealed by the unique phenotypes in PIKE knock-out mice will be discussed as well.
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