Menopause, postmenopausal hormone use and serum uric acid levels in US women--the Third National Health and Nutrition Examination Survey.
Menopause, postmenopausal hormone use and serum uric acid levels in US women--the Third National Health and Nutrition Examination Survey.
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DOI：
10.1186/ar2519
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发表时间：
2008
影响因子：
4.9
通讯作者：
Choi, Hyon K.
中科院分区：
文献类型：
--
作者：
Hak, A. Elisabeth;Choi, Hyon K.
尽管痛风在老年女性人群中普遍存在，但女性激素的影响尚未得到全面研究。我们评估并量化了绝经、绝经后激素使用和血清尿酸水平之间的潜在独立关联，这些关联来自全国范围内具有代表性的女性样本。利用第三次全国健康与营养调查（1988 ~ 1994）中7662名20岁及以上妇女的资料，我们研究了绝经、绝经后激素使用和血清尿酸水平之间的关系。我们使用多元线性回归来校正高尿酸血症的其他危险因素，如饮食因素、年龄、肥胖、饮酒、肾功能、高血压和利尿剂使用。绝经与血清尿酸水平升高有关。校正协变量后，自然绝经和手术绝经妇女的血清尿酸水平分别比绝经前妇女高0.34 mg/dl（95%置信区间[CI]，0.19 - 0.49）和0.36 mg/dl（95% CI，0.14 - 0.57）。目前绝经后激素的使用与绝经后妇女较低的血清尿酸水平相关（多变量差异，0.24 mg/dl [95% CI，0.11 - 0.36]）。血清尿酸水平随年龄类别的增加而增加（20 - 29岁和70岁及以上之间的粗差异= 1.03 mg/dl，趋势p < 0.001），但在调整其他协变量后，这种增加不存在（趋势p = 0.66）。这些来自美国妇女的全国代表性样本的研究结果表明，绝经与较高的血清尿酸水平独立相关，而绝经后激素的使用与绝经后妇女的较低尿酸水平相关。与年龄相关的女性血清尿酸水平升高可能与绝经和其他年龄相关因素有关。
Despite the substantial prevalence of gout in the ageing female population, female hormonal influence has not been comprehensively examined. We evaluated and quantified the potential independent association between menopause, postmenopausal hormone use and serum uric acid levels in a nationally representative sample of women. Using data from 7662 women aged 20 years and older in the Third National Health and Nutrition Examination Survey (1988 to 1994), we examined the relation between menopause, postmenopausal hormone use and serum uric acid levels. We used multivariate linear regression to adjust for other risk factors for hyperuricaemia such as dietary factors, age, adiposity, alcohol use, renal function, hypertension and diuretic use. Menopause was associated with higher serum uric acid levels. After adjusting for covariates, serum uric acid levels among women with natural menopause and surgical menopause were greater than premenopausal women by 0.34 mg/dl (95% confidence interval [CI], 0.19 to 0.49) and 0.36 mg/dl (95% CI, 0.14 to 0.57), respectively. Current postmenopausal hormone use was associated with a lower serum uric acid level among postmenopausal women (multivariate difference, 0.24 mg/dl [95% CI, 0.11 to 0.36]). The serum uric acid levels increased with increasing age categories (crude difference between 20 to 29 years and 70 years and over = 1.03 mg/dl, p for trend < 0.001), but this increase was not present after adjusting for other covariates (p for trend = 0.66). These findings from a nationally representative sample of US women indicate that menopause is independently associated with higher serum uric acid levels, whereas postmenopausal hormone use is associated with lower uric acid levels among postmenopausal women. The age-associated increase in serum uric acid levels in women may be explained by menopause and other age-related factors.
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影响因子：
13.2
作者：
Kramer, HM;Curhan, G
通讯作者：
Curhan, G
影响因子：
5.6
作者：
Simon, JA;Lin, F;Bittner, V
通讯作者：
Bittner, V
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作者：
STURGE, RA;SCOTT, JT;BUCHANAN, WW
通讯作者：
BUCHANAN, WW
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168.9
作者：
Sumino, H;Ichikawa, S;Sakamaki, T
通讯作者：
Sakamaki, T
影响因子：
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作者：
FESKANICH, D;RIMM, EB;WILLETT, WC
通讯作者：
WILLETT, WC