Influence of Semifluorinated Alkane Surface Domains on Phase Behavior and Linear and Nonlinear Viscoelasticity of Phospholipid Monolayers.
Influence of Semifluorinated Alkane Surface Domains on Phase Behavior and Linear and Nonlinear Viscoelasticity of Phospholipid Monolayers.
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半氟化烷烃表面域对磷脂单层相行为及线性和非线性粘弹性的影响
DOI：
10.1021/acs.langmuir.9b03521
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发表时间：
--
期刊：
影响因子：
--
通讯作者：
M. Tanaka
中科院分区：
文献类型：
--
作者：
S. Mielke;X. Liu;M.P. Krafft;M. Tanaka
半氟化烷烃在空气/水界面自组装成30-40纳米大的表面域（半束）。稳定涂有脂质的微泡已引起越来越多的关注，这些微泡被用于增强超声成像的对比度。虽然以前的研究表明，半氟化烷烃增加磷脂膜的稳定性，但对半氟化烷烃如何影响脂质包被微泡的相行为和力学性能知之甚少。作为一种定义良好的微泡表面模型，我们在空气/水界面制备了由磷脂和半氟化烷烃混合物组成的单层膜，并研究了半氟化烷烃半束对磷脂单层膜的相行为和界面粘弹性的影响。半束细胞与磷脂相分离并在相边界处聚集，这强烈地调节了固体磷脂结构域之间的相关性。有趣的是，我们发现半氟化烷烃和磷脂的混合单层具有与磷脂单层相当的线性和非线性粘弹性。由于半氟化烷烃和磷脂的混合使人们能够克服纯半氟化烷烃固有的低稳定性，而微气泡的表面积由于气体部分溶解到水相而发生变化，因此这是超声诊断中微气泡稳定涂层的一种很有前途的策略。
Semifluorinated alkanes self-assemble into 30–40 nm-large surface domains (hemimicelles) at the air/water interface. They have been drawing increasing attention to stabilize microbubbles coated with lipids, which are used for enhancing the contrast in sonographic imaging. Although previous studies suggested that semifluorinated alkanes increase the stability of phospholipid membranes, little is known about how semifluorinated alkanes influence phase behaviors and mechanical properties of lipid-coated microbubbles. As a well-defined model of microbubble surfaces, we prepared monolayers consisting of a mixture of phospholipids and semifluorinated alkanes at the air/water interface and investigated the influence of hemimicelles of semifluorinated alkanes on the phase behavior and interfacial viscoelastic properties of phospholipid monolayers. Hemimicelles are phase-separated from phospholipids and accumulate at the phase boundary, which strongly modulates the correlation between solid phospholipid domains. Intringuingly, we found that the mixed monolayer of semifluorinated alkanes and phospholipids possesses linear and nonlinear viscoelastic properties comparable to those of phospholipid monolayers. Since the mixing of semifluorinated alkanes and phospholipids enables one to overcome the intrinsically low stability of pure semifluorinated alkanes against the change in the surface area of microbubbles through the partial dissolution of gas into the aqueous phase, this is a promising strategy for the stable coating of microbubbles in ultrasound diagnosis.
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影响因子：
3.9
作者：
Bertilla, SM;Thomas, JL;Krafft, MP
通讯作者：
Krafft, MP
氟碳暴露模式显着影响气/液界面处的磷脂单层行为：对微泡尺寸和稳定性的影响。
DOI：
10.1021/acs.langmuir.8b03546
发表时间：
2018
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Danjie Shi;Xianhe Liu;C. Counil;M. Krafft
通讯作者：
M. Krafft
限制在空气/水界面的高度有序、二维金属纳米颗粒组件的非线性粘弹性
DOI：
10.1021/acs.langmuir.8b02713
发表时间：
2018
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
S. Masuda;S. Mielke;F. Amadei;A. Yamamoto;P. Wdaang;T. Taniguchi;K. Yoshikawa; K. Tama;M. Tanaka
通讯作者：
M. Tanaka
富全氟己烷气氛对空气-水界面自组装半氟化烷烃粘弹性和结构有序的影响
DOI：
10.1002/cphc.201900316
发表时间：
2019
期刊：
Chemphyschem : a European journal of chemical physics and physical chemistry
影响因子：
--
作者：
S. Mielke;W. Abuillan;M. Veschgini;X. Liu;O. Konovalov;M.P. Krafft;M. Tanaka
通讯作者：
M. Tanaka
相变温度附近含有偶氮苯衍生物的磷脂双层的渗透性增强
DOI：
--
发表时间：
1995
期刊：
影响因子：
--
作者：
Motomu Tanaka;Tomoo Sato;Y. Yonezawa
通讯作者：
Y. Yonezawa