Salient responsiveness of parabrachial neurons to the conditioned stimulus after the acquisition of taste aversion learning in rats
Salient responsiveness of parabrachial neurons to the conditioned stimulus after the acquisition of taste aversion learning in rats
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大鼠获得味觉厌恶学习后臂旁神经元对条件刺激的显着反应
DOI：
10.1016/s0306-4522(97)00188-7
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发表时间：
1997
期刊：
影响因子：
3.3
通讯作者：
Takashi Yamamoto
中科院分区：
文献类型：
--
作者：
T. Shimura;Hiroki Tanaka;Takashi Yamamoto
脑桥臂旁核被认为是获得条件性味觉厌恶的最关键区域之一，条件性味觉厌恶是味觉和疾病的联想学习。为了进一步阐明臂旁核可能参与条件性味觉厌恶，我们记录了在乌拉坦深度麻醉下大鼠臂旁核对味觉刺激的神经元反应。将动物分为两组：条件味觉厌恶组，在味觉刺激与腹腔注射LiCl（非条件刺激）配对呈现后获得对0.1M NaCl（条件刺激）的味觉厌恶，对照组在实验前仅接受非条件刺激。与对照组相比，条件性味觉厌恶组的味觉反应神经元对 0.1M 以下的 NaCl 表现出较大的反应，但对 0.3M 和 0.5M NaCl 的反应相似。此外，层次聚类分析显示，与对照组相比，条件性味觉厌恶组神经元对钠盐的反应具有很强的相似性。这些结果表明，对 NaCl 的厌恶调节改变了臂旁单位，使得钠味比其他味觉更显着。这种修饰可能反映了在没有前脑结构支持的情况下持续存在的长期可塑性变化，并且将促进条件刺激的味觉辨别，这是条件动物所需要的。
The pontine parabrachial nucleus is considered to be one of the most critical regions for the acquisition of conditioned taste aversion which is an associative learning of taste and illness. To further clarify the possible involvement of the parabrachial nucleus in conditioned taste aversion, we recorded neuronal responses to taste stimuli from the parabrachial nucleus of rats under deep urethane anaesthesia. Animals were separated into two groups: the conditioned taste aversion group that had acquired a taste aversion to 0.1M NaCl (conditioned stimulus) after paired presentations of the taste stimulus with intraperitoneal injection of LiCl (unconditioned stimulus), and the control group that had received only the unconditioned stimulus before experiments. Taste-responsive neurons in the conditioned taste aversion group showed larger responses to NaCl at below 0.1M, but similar responses to 0.3M and 0.5M NaCl when compared with those in the control group. Furthermore, hierarchical cluster analyses revealed a strong similarity among responses to sodium salts in neurons of the conditioned taste aversion group compared with the control group. These results suggest that the aversive conditioning to NaCl modified parabrachial units so that the sodium taste was more salient than other tastes. This modification may reflect a long-term plastic change persisting without support of forebrain structures, and would facilitate the gustatory discrimination of the conditioned stimulus, which is required by conditioned animals.
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臂旁核病变和条件性味觉厌恶：支持联想缺陷的证据。
影响因子：
1.9
作者：
Reilly,S;Grigson,PS;Norgren,R
通讯作者：
Norgren,R
臂旁味觉损伤损害大鼠的味觉厌恶学习。
影响因子：
1.9
作者：
Spector,AC;Norgren,R;Grill,HJ
通讯作者：
Grill,HJ
行为大鼠臂旁味觉神经元的反应。
影响因子：
2.5
作者：
Nishijo,H;Norgren,R
通讯作者：
Norgren,R
脑干损伤和味觉功能：I. 大鼠短暂摄入试验期间孤束核的作用。
DOI：
--
发表时间：
1997
期刊：
Behavioral neuroscience.
影响因子：
--
作者：
Shimura,T;Norgren,R;Grigson,PS;Norgren,R
通讯作者：
Norgren,R
DOI：
--
发表时间：
1997
期刊：
Behavioral neuroscience.
影响因子：
--
作者：
Grigson,PS;Shimura,T;Norgren,R
通讯作者：
Norgren,R