K(+) channels and cell cycle progression in tumor cells.
K(+) channels and cell cycle progression in tumor cells.
复制标题
DOI：
10.3389/fphys.2013.00220
复制
发表时间：
2013
影响因子：
4
通讯作者：
Ahidouch A
中科院分区：
文献类型：
--
作者：
Ouadid-Ahidouch H;Ahidouch A
K+离子在许多细胞过程中起着重要作用。K+信号的失控与多种疾病有关，如高血压、动脉粥样硬化或糖尿病。K+离子对膜电位的设定、钙离子内流的驱动力以及生长细胞体积的调节都起着重要作用。此外，人们越来越认识到K+通道通过一种新的信号机制控制细胞的增殖，这种信号机制不依赖于离子通量而被触发和调节。在癌症中，K+通道的异常表达、调节和/或亚块化可以改变汇聚在细胞周期机制上的下游信号。不同的K+通道参与细胞周期进程，只有在细胞周期的特定阶段才需要。与这一观点一致，Eag1和HERG通道的表达随着细胞周期的变化而波动。尽管我们已经获得了知识，但我们对K+通道在癌细胞中功能的理解还需要进一步的研究。这些包括确定控制细胞周期机制的分子机制。通过了解K+通道如何调控癌细胞的细胞周期进程，我们将深入了解癌细胞如何颠覆K+信号及其下游靶点的增殖需求。
K+ ions play a major role in many cellular processes. The deregulation of K+ signaling is associated with a variety of diseases such as hypertension, atherosclerosis, or diabetes. K+ ions are important for setting the membrane potential, the driving force for Ca2+ influx, and regulate volume of growing cells. Moreover, it is increasingly recognized that K+ channels control cell proliferation through a novel signaling mechanisms triggered and modulated independently of ion fluxes. In cancer, aberrant expression, regulation and/or sublocalization of K+ channels can alter the downstream signals that converge on the cell cycle machinery. Various K+ channels are involved in cell cycle progression and are needed only at particular stages of the cell cycle. Consistent with this idea, the expression of Eag1 and HERG channels fluctuate along the cell cycle. Despite of acquired knowledge, our understanding of K+ channels functioning in cancer cells requires further studies. These include identifying the molecular mechanisms controlling the cell cycle machinery. By understanding how K+ channels regulate cell cycle progression in cancer cells, we will gain insights into how cancer cells subvert the need for K+ signal and its downstream targets to proliferate.
登录
查看更多内容
影响因子：
64.8
作者：
DECOURSEY, TE;CHANDY, KG;CAHALAN, MD
通讯作者：
CAHALAN, MD
影响因子：
5.6
作者：
Borowiec, Anne-Sophie;Hague, Frederic;Ouadid-Ahidouch, Halima
通讯作者：
Ouadid-Ahidouch, Halima
DOI：
10.1073/pnas.94.2.537
发表时间：
1997-01-21
影响因子：
11.1
作者：
Bruggemann, A;Stuhmer, W;Pardo, LA
通讯作者：
Pardo, LA
影响因子：
3.3
作者：
Cherubini, A;Hofmann, G;Arcangeli, A
通讯作者：
Arcangeli, A
影响因子：
11.4
作者：
Day, ML;Johnson, MH;Cook, DI
通讯作者：
Cook, DI