Integrated long-term multifunctional pediatric mechanical circulatory assist device.
Integrated long-term multifunctional pediatric mechanical circulatory assist device.
复制标题
DOI：
10.1111/aor.13863
复制
发表时间：
2021-05
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
作者：
仍然存在有限的、可行的心室辅助装置技术选项来支持小儿心力衰竭的功能障碍状态。为了满足这一需求，我们正在开发一种磁悬浮的多功能泵送技术，该技术将两个血泵以串联配置独特地集成在单个设备外壳中。该器械能够根据临床管理或支持儿科患者生长发育的需要从一种泵的使用切换到另一种泵的使用。在这里，我们提出了初始设计，我们进行了虚拟配合研究，田口设计优化方法，迭代设计，以开发泵的几何形状。使用计算工具来估计压力产生、容量输送、液压效率、流体应力水平、暴露于应力的时间、血液损伤指数和叶轮上的流体力。使用水甘油溶液在流动回路中测试泵的原型。两种设计均证明了产生目标压力和流量的能力。血液损伤估计值低于阈值水平并达到设计要求;但是，最大标量应力水平高于目标限值。径向力和轴向力分别小于1 N和10 N。物理原型的性能数据趋势与理论预期相关。离心原型能够产生比数值预测略高的压力上升。相比之下，轴向原型优于计算研究。实验数据具有可重复性和重现性。这项研究的结果是有希望的，并将继续发展。
There continues to be limited, viable ventricular assist device technology options to support the dysfunctional states of pediatric heart failure. To address this need, we are developing a magnetically suspended, versatile pumping technology that uniquely integrates two blood pumps in a series configuration within a single device housing. This device enables operational switching from the usage of one pump to another as needed for clinical management or to support growth and development of the pediatric patient. Here, we present the initial design where we conducted a virtual fit study, the Taguchi Design Optimization Method, iterative design to develop pump geometries. Computational tools were used to estimate the pressure generation, capacity delivery, hydraulic efficiency, fluid stress levels, exposure time to stresses, blood damage index, and fluid forces on the impellers. Prototypes of the pumps were tested in a flow loop using a water-glycerin solution. Both designs demonstrated the capability to generate target pressures and flows. Blood damage estimations were below threshold levels and achieved design requirements; however, maximum scalar stress levels were above the target limit. Radial and axial forces were less than 1 N and 10 N, respectively. The performance data trends for physical prototypes correlated with theoretical expectations. The centrifugal prototype was able to generate slightly higher pressure rises than numerical predictions. In contrast, the axial prototype outperformed the computational studies. Experimental data were both repeatable and reproducible. The findings from this research are promising, and development will continue.
登录
查看更多内容
影响因子：
158.5
作者：
Rose, EA;Gelijns, AC;Meier, P
通讯作者：
Meier, P
影响因子：
4.2
作者：
Throckmorton, Amy L.;Untaroiu, Alexandrina;Olsen, Don B.
通讯作者：
Olsen, Don B.
影响因子：
8.9
作者：
Blume, Elizabeth D.;VanderPluym, Christina;Rosenthal, DavidN.
通讯作者：
Rosenthal, DavidN.
影响因子：
2.4
作者：
Mascio, Christopher E.
通讯作者：
Mascio, Christopher E.
DOI：
10.5293/ijfms.2019.12.4.322
发表时间：
2019-01-01
影响因子：
--
作者：
Bashiri, Mohamad;Derakhshan, Shahram;Shahrabi, Jamal
通讯作者：
Shahrabi, Jamal