The use of neurotrophin therapy in the inner ear to augment cochlear implantation outcomes.
The use of neurotrophin therapy in the inner ear to augment cochlear implantation outcomes.
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DOI：
10.1002/ar.22586
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发表时间：
2012-11
影响因子：
2
通讯作者：
Raphael, Yehoash
中科院分区：
文献类型：
--
作者：
Budenz, Cameron L.;Pfingst, Bryan E.;Raphael, Yehoash
这篇综述将涵盖神经营养因子在内耳发育、神经元维持、神经元过程再生和临床应用中的作用，包括可能增强人工耳蜗植入功能。重度至极重度耳聋通常是继发于耳蜗机械感觉细胞的损失或损伤，并且通常伴有外周听觉神经结构的相关损失，特别是螺旋神经节神经元和外周听觉纤维。耳蜗植入术是目前治疗重度至极重度耳聋的最佳听力康复策略。这些植入物通过直接电刺激耳蜗内的残余听觉神经结构来工作。在动物模型中，当对受损的耳蜗给药时，神经营养因子，特别是BDNF和NT 3，已显示出显着改善螺旋神经节神经元存活并刺激外周听觉纤维再生。在动物模型中，神经营养因子与人工耳蜗植入联合给药导致结果的电生理和心理物理测量的显著改善。虽然在这些疗法可以应用于临床之前必须进行进一步的研究，但用于内耳的神经营养因子疗法在提高人工耳蜗植入结果和治疗听力损失方面显示出巨大的前景。
This review will cover the roles of neurotrophins in inner ear development, neuronal maintenance, neuronal process regeneration, and clinical applications including possible augmentation of cochlear implant function. Severe to profound deafness is most often secondary to a loss of or injury to cochlear mechanosensory cells, and there is often an associated loss of the peripheral auditory neural structures, specifically the spiral ganglion neurons and peripheral auditory fibers. Cochlear implantation is currently our best hearing rehabilitation strategy for severe to profound deafness. These implants work by directly electrically stimulating the remnant auditory neural structures within the deafened cochlea. When administered to the deafened cochlea in animal models, neurotrophins, specifically BDNF and NT3, have been shown to dramatically improve spiral ganglion neuron survival and stimulate peripheral auditory fiber regrowth. In animal models, neurotrophins administered in combination with cochlear implantation has resulted in significant improvements in the electrophysiological and psychophysical measures of outcome. While further research must be done before these therapies can be applied clinically, neurotrophin therapies for the inner ear show great promise in enhancing cochlear implant outcomes and the treatment of hearing loss.
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影响因子：
2.8
作者：
Cohen, LT;Saunders, E;Cowan, RSC
通讯作者：
Cowan, RSC
影响因子：
2.8
作者：
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影响因子：
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作者：
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通讯作者：
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