Personalized medicine in psychiatry: problems and promises.

Personalized medicine in psychiatry: problems and promises.
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精神病学中的个性化医疗:问题和承诺。

DOI:
10.1186/1741-7015-11-132
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发表时间:
2013-05-16
期刊:
影响因子:
9.3
通讯作者:
Nemeroff CB
Nemeroff CB
中科院分区:
医学1区
文献类型:
--
作者:
Ozomaro U;Wahlestedt C;Nemeroff CB

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个体化医疗的中心主题是一个前提,即个体独特的生理特征在疾病易感性和对特定治疗的反应中都起着重要作用。因此,个性化医疗的主要目标是预测个体对疾病的易感性,实现准确的诊断,并优化最有效和最有利的治疗反应。在精神病学中实现个性化医疗的目标是值得称赞的,因为它的实现应该伴随着发病率和死亡率的显著降低。在这篇综述中,我们总结了一些研究,这些研究为重度抑郁症、双相情感障碍和精神分裂症的个性化治疗奠定了基础。此外,我们提出了可能推进精神病学个性化医疗的新兴应用,重点是新的生物标志物和神经成像。
The central theme of personalized medicine is the premise that an individual’s unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual’s susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging.
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