Neural correlates of emotional reactivity and regulation in youth with and without anxiety.
Neural correlates of emotional reactivity and regulation in youth with and without anxiety.
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有和没有焦虑的青年人情绪反应性和调节的神经相关性。
DOI：
10.1002/da.23154
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发表时间：
2021-08
影响因子：
7.4
通讯作者：
Peris TS
中科院分区：
文献类型：
--
作者：
Padgaonkar NT;Phuong Uy J;DePasque S;Galván A;Peris TS
与同龄人相比，患有焦虑症的年轻人很难控制自己的情绪，但这种差异的神经基础尚未得到研究。有（n = 37）和无（n = 24）焦虑症的青年（Mage = 13.6; range = 8-17）在接受功能性磁共振成像时完成了认知再评估任务。情绪反应和调节、功能激活和β系列连通性在各组间进行了比较。各组在情绪反应或调节方面没有差异。然而，焦虑的年轻人在观看有和没有调节的厌恶图像后的额边缘激活，以及没有调节的影响评分，都更高。两组都没有表现出与年龄相关的调节变化，尽管焦虑的年轻人随着年龄的增长反应越来越少。较强的杏仁核-腹内侧前额叶皮层连通性与对照组青少年的焦虑程度有关，而焦虑青少年的焦虑程度较低。焦虑青年在指导下进行调节，调节能力与年龄无关。即使在重新评估后，观看厌恶图像也与前额边缘激活增强有关。青少年焦虑症的情绪失调可能源于情绪的升高和对厌恶刺激的自下而上的神经生物学反应。研究结果表明，治疗的重点是减少最初的情绪反应和增强调节能力。
Youth with anxiety disorders struggle with managing emotions relative to peers, but the neural basis of this difference has not been examined. Youth (Mage = 13.6; range = 8–17) with (n = 37) and without (n = 24) anxiety disorders completed a cognitive reappraisal task while undergoing functional magnetic resonance imaging. Emotional reactivity and regulation, functional activation, and beta-series connectivity were compared across groups. Groups did not differ on emotional reactivity or regulation. However, fronto-limbic activation after viewing aversive imagery with and without regulation, as well as affect ratings without regulation, were higher for anxious youth. Neither group demonstrated age-related changes in regulation, though anxious youth became less reactive with age. Stronger amygdala-ventromedial prefrontal cortex connectivity related to greater anxiety in control youth, but less anxiety in anxious youth. Anxious youth regulated when instructed, but regulation ability did not relate to age. Viewing aversive imagery related to heightened fronto-limbic activation even after reappraisal. Emotion dysregulation in youth anxiety disorders may stem from heightened emotionality and potent bottom-up neurobiological responses to aversive stimuli. Findings suggest the importance of treatments focused on both reducing initial emotional reactivity and bolstering regulatory capacity.
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影响因子：
5.7
作者：
Dosenbach NUF;Koller JM;Earl EA;Miranda-Dominguez O;Klein RL;Van AN;Snyder AZ;Nagel BJ;Nigg JT;Nguyen AL;Wesevich V;Greene DJ;Fair DA
通讯作者：
Fair DA
DOI：
10.1016/j.chc.2012.05.001
发表时间：
2012-07-01
影响因子：
2.4
作者：
Beesdo-Baum, Katja;Knappe, Susanne
通讯作者：
Knappe, Susanne
影响因子：
6.4
作者：
Legerstee, Jeroen S.;Garnefski, Nadia;Utens, Elisabeth M. W. J.
通讯作者：
Utens, Elisabeth M. W. J.
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
DOI：
10.1016/j.jaac.2010.05.017
发表时间：
2010-10
影响因子：
13.3
作者：
Merikangas KR;He JP;Burstein M;Swanson SA;Avenevoli S;Cui L;Benjet C;Georgiades K;Swendsen J
通讯作者：
Swendsen J