AMPK Function in Mammalian Spermatozoa.
AMPK Function in Mammalian Spermatozoa.
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DOI：
10.3390/ijms19113293
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发表时间：
2018-10-23
影响因子：
5.6
通讯作者：
Bragado MJ
中科院分区：
文献类型：
--
作者：
Martin-Hidalgo D;Hurtado de Llera A;Calle-Guisado V;Gonzalez-Fernandez L;Garcia-Marin L;Bragado MJ
AMP激活的蛋白激酶AMPK通过抑制合成代谢途径和同时刺激分解代谢途径来控制代谢，从而调节细胞能量。鉴于AMPK在细胞代谢中的中心调节作用，AMPK活性及其调节一直是相关研究的焦点，尽管只有少数研究关注AMPK在控制精子受精能力中的功能。本文综述了AMPK在哺乳动物精子中的作用。AMPK活性的参与被描述在成熟精子的主要生理功能方面，特别是在适应波动的细胞外介质的适当的精子运动性的调节，精子膜的完整性的维持，和线粒体膜电位。此外，对哺乳动物精子中AMPK激活的细胞内信号通路进行了综述。我们还讨论了AMPK在辅助生殖技术中的作用，特别是在精液冷冻保存和保存（17 °C）期间。最后，我们加强了AMPK作为精子中的关键信号激酶的想法，作为代谢能量和精子受精能力之间的重要接头/桥梁。
AMP-activated protein kinase AMPK regulates cellular energy by controlling metabolism through the inhibition of anabolic pathways and the simultaneous stimulation of catabolic pathways. Given its central regulator role in cell metabolism, AMPK activity and its regulation have been the focus of relevant investigations, although only a few studies have focused on the AMPK function in the control of spermatozoa’s ability to fertilize. This review summarizes the known cellular roles of AMPK that have been identified in mammalian spermatozoa. The involvement of AMPK activity is described in terms of the main physiological functions of mature spermatozoa, particularly in the regulation of suitable sperm motility adapted to the fluctuating extracellular medium, maintenance of the integrity of sperm membranes, and the mitochondrial membrane potential. In addition, the intracellular signaling pathways leading to AMPK activation in mammalian spermatozoa are reviewed. We also discuss the role of AMPK in assisted reproduction techniques, particularly during semen cryopreservation and preservation (at 17 °C). Finally, we reinforce the idea of AMPK as a key signaling kinase in spermatozoa that acts as an essential linker/bridge between metabolism energy and sperm’s ability to fertilize.
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