Lung cancer-initiating cells: a novel target for cancer therapy.
Lung cancer-initiating cells: a novel target for cancer therapy.
复制标题
肺癌起始细胞：癌症治疗的一个新靶点。
DOI：
10.1007/s11523-012-0247-4
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发表时间：
2013-09
影响因子：
5.4
通讯作者：
Steel, Jason C.
中科院分区：
文献类型：
--
作者：
Morrison, Brian J.;Morris, John C.;Steel, Jason C.
肺癌是一个主要的公共卫生问题，导致的死亡人数比任何其他癌症都要多。迫切需要更好地了解这种疾病的生物学特性并改进治疗方法。越来越多的证据支持这一概念，即一种罕见且特殊的癌细胞群，即所谓的具有干细胞样特征的癌症起始细胞，负责肿瘤的生长、维持和复发。癌症起始细胞还表现出使它们对放射和化疗具有抵抗力的特征，因此它们被认为在治疗失败中发挥了作用。这导致了这样的假设：不加区别地杀死肿瘤细胞的传统疗法不如选择性针对癌症起始细胞的疗法有效。研究肺癌中假定的癌症起始细胞将极大地有助于了解这种疾病的起源，并可能通过建议用于进一步分离该群体进行研究或选择性靶向这些细胞的标记物，从而带来新的治疗方法。本综述将讨论（1）肺癌，（2）干细胞，以及癌起始细胞在肿瘤发生中的作用； (3) 与肺癌起始细胞相关的标志物和功能特征； (4)选择性靶向该肿瘤细胞亚群的潜力。
Lung cancer is a major public health problem causing more deaths than any other cancer. A better understanding of the biology of this disease and improvements in treatment are greatly needed. Increasing evidence supports the concept that a rare and specialized population of cancer cells, so-called cancer-initiating cells with stem cell-like characteristics, is responsible for tumor growth, maintenance, and recurrence. Cancer-initiating cells also exhibit characteristics that render them resistant to both radiation and chemotherapy, and therefore they are believed to play a role in treatment failure. This has led to the hypothesis that traditional therapies that indiscriminately kill tumor cells will not be as effective as therapies that selectively target cancer-initiating cells. Investigating putative cancer-initiating cells in lung cancer will greatly benefit the understanding of the origins of this disease and may lead to novel approaches to therapy by suggesting markers for use in either further isolating this population for study or for selectively targeting these cells. This review will discuss (1) lung cancer, (2) stem cells, and the role of cancer-initiating cells in tumorigenesis; (3) markers and functional characteristics associated with lung cancer-initiating cells; and (4) the potential to selectively target this subpopulation of tumor cells.
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影响因子：
8
作者：
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通讯作者：
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