NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.
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DOI：
10.1038/s41467-018-04283-9
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发表时间：
2018-05-09
影响因子：
16.6
通讯作者：
Narita M
中科院分区：
文献类型：
--
作者：
Parry AJ;Hoare M;Bihary D;Hänsel-Hertsch R;Smith S;Tomimatsu K;Mannion E;Smith A;D'Santos P;Russell IA;Balasubramanian S;Kimura H;Samarajiwa SA;Narita M
衰老细胞与周围的微环境相互作用，以达到潜水功能的结果。自主和非自主。致癌性RAS诱导的感官（RIS）细胞暴露了染色质的可及性，可抑制SAHF，并在这种情况下增加染色质的可及性。在通过机械上的细胞 - 细胞接触的相邻细胞中，我们表明Notch信号反映了染色质建筑蛋白HMGA1，在多个人类癌症中发现，HMGA1不仅参与了SAHF，而且还参与了RIS驱动的染色质访问性。建筑学。
Notch可以以细胞接触的方式驱动感应方式。
Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique senescence phenotype in adjacent cells by specifically upregulating the NOTCH ligand JAG1. Here we show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously. In addition to senescence-associated heterochromatic foci (SAHF), oncogenic RAS-induced senescent (RIS) cells exhibit a massive increase in chromatin accessibility. NOTCH signalling suppresses SAHF and increased chromatin accessibility in this context. Strikingly, NOTCH-induced senescent cells, or cancer cells with high JAG1 expression, drive similar chromatin architectural changes in adjacent cells through cell–cell contact. Mechanistically, we show that NOTCH signalling represses the chromatin architectural protein HMGA1, an association found in multiple human cancers. Thus, HMGA1 is involved not only in SAHFs but also in RIS-driven chromatin accessibility. In conclusion, this study identifies that the JAG1–NOTCH–HMGA1 axis mediates the juxtacrine regulation of chromatin architecture. Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.
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影响因子：
4.5
作者：
Chen A;Liu Y;Williams SM;Morris N;Buchner DA
通讯作者：
Buchner DA
影响因子：
16
作者：
Chandra, Tamir;Kirschner, Kristina;Thuret, Jean-Yves;Pope, Benjamin D.;Ryba, Tyrone;Newman, Scott;Ahmed, Kashif;Samarajiwa, Shamith A.;Salama, Rafik;Carroll, Thomas;Stark, Rory;Janky, Rekin's;Narita, Masako;Xue, Lixiang;Chicas, Agustin;Nunez, Sabrina;Janknecht, Ralf;Hayashi-Takanaka, Yoko;Wilson, Michael D.;Marshall, Aileen;Odom, Duncan T.;Babu, M. Madan;Bazett-Jones, David P.;Tavare, Simon;Edwards, Paul A. W.;Lowe, Scott W.;Kimura, Hiroshi;Gilbert, David M.;Narita, Masashi
通讯作者：
Narita, Masashi
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
11.2
作者：
Fedele, M;Fidanza, V;Fusco, A
通讯作者：
Fusco, A
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK