Lithium protects against glucocorticoid induced neural progenitor cell apoptosis in the developing cerebellum.
Lithium protects against glucocorticoid induced neural progenitor cell apoptosis in the developing cerebellum.
复制标题
锂可以预防发育中的小脑中糖皮质激素诱导的神经祖细胞细胞凋亡。
DOI：
10.1016/j.brainres.2013.12.014
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发表时间：
2014-01-30
期刊：
影响因子：
2.9
通讯作者：
Noguchi, Kevin K.
中科院分区：
文献类型：
--
作者：
Cabrera, Omar;Dougherty, Joseph;Singh, Sukrit;Swiney, Brant S.;Farber, Nuri B.;Noguchi, Kevin K.
关键词：
呼吸功能障碍是与早产相关的最常见的死亡原因之一。在美国，7-10%的孕妇接受产前糖皮质激素（GC）治疗，而大约19%的极低出生体重儿接受产后GC治疗。临床研究表明，GC治疗会导致永久性神经运动和认知缺陷，并阻碍小脑生长。我们以前报道过GC介导的神经前体细胞（NPC）凋亡可能是小脑神经病理学的原因。本研究的目的是确定锂是否在体内和体外保护NPC免受GC神经凋亡。考虑到它可以保护免受一系列脑损伤，我们假设锂会显著减弱GC诱导的NPC毒性。我们报告，急性锂预处理提供了有效的，细胞内在的神经保护对GC诱导的NPC毒性在体内和体外。
Respiratory dysfunction is one of the most common causes of death associated with premature birth. In the United States, 7–10% of pregnant women receive antenatal glucocorticoid (GC) therapy, while approximately 19% of very low birth weight infants receive postnatal GC therapy. Clinical research suggests that GC treatment causes permanent neuromotor and cognitive deficits and stunts cerebellar growth. We previously reported that GC-mediated neural progenitor cell (NPC) apoptosis may be responsible for cerebellar neuropathology. The goal of the current study was to determine whether lithium protects NPCs from GC neuroapoptosis in vivo and in vitro. Given that it protects against a range of brain insults, we hypothesized that lithium would significantly attenuate GC induced NPC toxicity. We report that acute lithium pretreatment provides potent, cell-intrinsic neuroprotection against GC induced NPC toxicity in vivo and in vitro.
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影响因子：
15.9
作者：
Heine, Vivi M.;Rowitch, David H.
通讯作者：
Rowitch, David H.
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通讯作者：
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