Protein protein interactions, evolutionary rate, abundance and age.
Protein protein interactions, evolutionary rate, abundance and age.
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DOI：
10.1186/1471-2105-7-128
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发表时间：
2006-03-13
影响因子：
3
通讯作者：
Deane CM
中科院分区：
文献类型：
--
作者：
Saeed R;Deane CM
蛋白质的进化速率和它的相互作用次数之间是否存在关系？这种关系已经被多次提出，基于一个生物学前提，即高度相互作用的蛋白质在其序列变化中将受到更多限制。然而，到目前为止，一些研究已经表达了相互矛盾的意见，存在或不存在这种关系。在这里，我们对多个数据集进行了大规模研究，以证明以前研究之间冲突的主要原因是使用不同但重叠的数据集。我们发现，缺乏相关性，在一个数据集中的相互作用的进化速率和数量之间的错误率。我们还表明，相关性是不是一个工件的基本分布的进化距离和相互作用，因此可能是生物相关的。此外，我们认为这种依赖性是由于基因表达水平，并找到了一些支持性证据。还观察到相互作用的数量和蛋白质的年龄之间的强烈的正相关性，我们表明这种关系是独立的表达水平。相互作用的数量和进化速率之间的相关性被观察到，但取决于所使用的数据集的准确性。然而，似乎蛋白质参与的相互作用的数量更多地取决于蛋白质的年龄，而不是它变化的速率。
Does a relationship exist between a protein's evolutionary rate and its number of interactions? This relationship has been put forward many times, based on a biological premise that a highly interacting protein will be more restricted in its sequence changes. However, to date several studies have voiced conflicting views on the presence or absence of such a relationship. Here we perform a large scale study over multiple data sets in order to demonstrate that the major reason for conflict between previous studies is the use of different but overlapping datasets. We show that lack of correlation, between evolutionary rate and number of interactions in a data set is related to the error rate. We also demonstrate that the correlation is not an artifact of the underlying distributions of evolutionary distance and interactions and is therefore likely to be biologically relevant. Further to this, we consider the claim that the dependence is due to gene expression levels and find some supporting evidence. A strong and positive correlation between the number of interactions and the age of a protein is also observed and we show this relationship is independent of expression levels. A correlation between number of interactions and evolutionary rate is observed but is dependent on the accuracy of the dataset being used. However it appears that the number of interactions a protein participates in depends more on the age of the protein than the rate at which it changes.
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