Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment.
Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment.
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DOI：
10.1093/ijnp/pyx088
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Robbins TW
中科院分区：
文献类型：
--
作者：
Fineberg NA;Apergis-Schoute AM;Vaghi MM;Banca P;Gillan CM;Voon V;Chamberlain SR;Cinosi E;Reid J;Shahper S;Bullmore ET;Sahakian BJ;Robbins TW
强迫行为是重复性、刻板的思维和行为，旨在减少伤害。越来越多的证据表明，介导行为抑制（运动抑制、认知灵活性缺失）、反转学习和习惯形成（从目标导向转变为习惯性反应）的神经认知机制在多种疾病中导致了强迫行为。在强迫症中，分布式网络扰动似乎集中在前额叶皮质、尾状核、壳核以及相关的神经回路周围。强迫症相关的注意定势转移缺陷与神经影像学上尾状核背侧和腹外侧前额叶皮质之间静息态功能连接性降低相关。相比之下，对强迫症症状的实验性激发会减少与目标导向行为控制有关的大脑区域（腹内侧前额叶皮质、尾状核）的神经激活，同时与习惯学习有关的区域（辅助运动前区、壳核）的激活相应增加。腹内侧前额叶皮质起着多方面的作用，整合情感评估过程、灵活行为和恐惧学习。一项关于巴甫洛夫恐惧反转的神经影像学研究发现，尽管强迫症患者在初始恐惧条件反射正常，但未能灵活更新恐惧反应，这表明强迫症中缺乏腹内侧前额叶皮质的安全信号，这可能会破坏外显的偶发事件知识，并可能有助于解释在强迫症等强迫性疾病中认知灵活性缺失、恐惧和焦虑处理之间的联系。
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder, distributed network perturbation appears focused around the prefrontal cortex, caudate, putamen, and associated neuro-circuitry. Obsessive compulsive disorder-related attentional set-shifting deficits correlated with reduced resting state functional connectivity between the dorsal caudate and the ventrolateral prefrontal cortex on neuroimaging. In contrast, experimental provocation of obsessive compulsive disorder symptoms reduced neural activation in brain regions implicated in goal-directed behavioral control (ventromedial prefrontal cortex, caudate) with concordant increased activation in regions implicated in habit learning (presupplementary motor area, putamen). The ventromedial prefrontal cortex plays a multifaceted role, integrating affective evaluative processes, flexible behavior, and fear learning. Findings from a neuroimaging study of Pavlovian fear reversal, in which obsessive compulsive disorder patients failed to flexibly update fear responses despite normal initial fear conditioning, suggest there is an absence of ventromedial prefrontal cortex safety signaling in obsessive compulsive disorder, which potentially undermines explicit contingency knowledge and may help to explain the link between cognitive inflexibility, fear, and anxiety processing in compulsive disorders such as obsessive compulsive disorder.
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DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A
影响因子：
10.6
作者：
Aron, AR;Poldrack, RA
通讯作者：
Poldrack, RA
影响因子：
7.6
作者：
Batistuzzo, Marcelo C.;Hoexter, Marcelo Q.;Lopes, Antonio C.
通讯作者：
Lopes, Antonio C.
DOI：
10.1080/14640748208400878
发表时间：
1982-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD
通讯作者：
ADAMS, CD
影响因子：
2.9
作者：
Afshar, Hamid;Roohafza, Hamidreza;Hafezian, Hasan
通讯作者：
Hafezian, Hasan