Overlapping genes in the human and mouse genomes.
Overlapping genes in the human and mouse genomes.
复制标题
人类和小鼠基因组中的重叠基因。
DOI：
10.1186/1471-2164-9-169
复制
发表时间：
2008-04-14
期刊：
影响因子：
4.4
通讯作者：
Zhang, Liqing
中科院分区：
文献类型：
--
作者：
Sanna, Chaitanya R.;Li, Wen-Hsiung;Zhang, Liqing
越来越多的证据表明，重叠基因在真核基因组中比以前认为的更为常见。在这项研究中，我们鉴定并表征了一组 13,484 对人-小鼠直系同源基因中的重叠基因。所研究的基因中约有 10% 是重叠基因，其中大多数是不同链重叠。大多数同链重叠是嵌入形式，而大多数不同链重叠不是嵌入的并且处于聚合转录方向。大多数同链重叠基因对显示出至少十倍的长度差异，远大于非重叠相邻基因对之间的长度差异。两个不同链重叠基因之间的长度差异不太显着。超过 27% 的不同链重叠关系在人类和小鼠之间共享，而同链重叠关系中只有约 8% 的保守性。在人类和小鼠之间不共享的同链和异链重叠中，超过 96% 的两个基因都位于不显示重叠的物种的相同染色体上。我们研究了两个物种中重叠和非重叠状态之间转变的原因，发现3'UTR变化在转变中起着重要作用。我们的研究有助于理解重叠基因和非重叠基因之间的进化转变，并证明非翻译区域的进化变化率很高。
Increasing evidence suggests that overlapping genes are much more common in eukaryotic genomes than previously thought. In this study we identified and characterized the overlapping genes in a set of 13,484 pairs of human-mouse orthologous genes. About 10% of the genes under study are overlapping genes, the majority of which are different-strand overlaps. The majority of the same-strand overlaps are embedded forms, whereas most different-strand overlaps are not embedded and in the convergent transcription orientation. Most of the same-strand overlapping gene pairs show at least a tenfold difference in length, much larger than the length difference between non-overlapping neighboring gene pairs. The length difference between the two different-strand overlapping genes is less dramatic. Over 27% of the different-strand-overlap relationships are shared between human and mouse, compared to only ~8% conservation for same-strand-overlap relationships. More than 96% of the same-strand and different-strand overlaps that are not shared between human and mouse have both genes located on the same chromosomes in the species that does not show the overlap. We examined the causes of transition between the overlapping and non-overlapping states in the two species and found that 3' UTR change plays an important role in the transition. Our study contributes to the understanding of the evolutionary transition between overlapping genes and non-overlapping genes and demonstrates the high rates of evolutionary changes in the un-translated regions.
登录
查看更多内容
TreeFam：动物基因家族系统发育树的精选数据库
影响因子：
14.9
作者：
Li, Heng;Coghlan, Avril;Ruan, Jue;Coin, Lachlan James;Heriche, Jean-Karim;Osmotherly, Lara;Li, Ruiqiang;Liu, Tao;Zhang, Zhang;Bolund, Lars;Wong, Gane Ka-Shu;Zheng, Weimou;Dehal, Paramvir;Wang, Jun;Durbin, Richard
通讯作者：
Durbin, Richard
影响因子：
4.4
作者：
Cooper, PR;Smilinich, NJ;Higgins, MJ
通讯作者：
Higgins, MJ
影响因子：
4.4
作者：
Kennerson, ML;Nassif, NT;Nicholson, GA
通讯作者：
Nicholson, GA
影响因子：
3.3
作者：
Krakauer, DC
通讯作者：
Krakauer, DC
影响因子：
64.8
作者：
SPENCER, CA;GIETZ, RD;HODGETTS, RB
通讯作者：
HODGETTS, RB