EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.
EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.
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DOI：
10.1016/j.ejca.2009.02.027
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Munck-Wikland E
中科院分区：
文献类型：
--
作者：
Ryott M;Wangsa D;Heselmeyer-Haddad K;Lindholm J;Elmberger G;Auer G;Avall Lundqvist E;Ried T;Munck-Wikland E
针对表皮生长因子受体(EGFR)的新的治疗药物已经被开发出来，尽管关于EGFR在口腔舌鳞状细胞癌(OTSCC)中的状态的临床信息有限。我们检测了78例OTSCC石蜡标本中EGFR蛋白的表达和基因拷贝数。78例肿瘤中均有EGFR蛋白表达，其中72%呈强阳性表达。54%的肿瘤具有较高的(≥四个基因拷贝)EGFR基因拷贝数。EGFR基因拷贝数与EGFR蛋白表达显著相关(P=0.002)。治疗前的EGFR染色强度与II期OTSCC术前放疗后的非病理性完全缓解有关。未发现EGFR状态与生存率之间的相关性。进展期肿瘤(II、III、IV期)的EGFR FISH结果显著高于I期(P=0.003)。非吸烟者在I、II期口腔鳞状细胞癌中EGFR基因拷贝数和蛋白过度表达显著高于吸烟者(P=0.001，P=0.009)。综上所述，我们发现EGFR在所有OTSCC中都有过表达，这使得这种类型的癌症对于探索以EGFR受体为靶点的新的治疗药物很有兴趣。
New promising therapeutic agents targeting epidermal growth factor receptor (EGFR) have been developed although clinical information concerning EGFR status in oral tongue squamous cell carcinoma (OTSCC) is limited. We investigated EGFR protein expression and gene copy numbers in 78 pretreatment OTSCC paraffin samples. EGFR protein expression was found in all 78 tumours, of which 72% showed an intense staining. Fifty-four percent of the tumours had high (≥four gene copies) EGFR gene copy numbers. EGFR gene copy number was significantly associated with EGFR protein expression (P = 0.002). Pretreatment EGFR staining intensity tended to be associated with non-pathological complete remission after preoperative radiotherapy for Stage II OTSCC. No correlation was found between EGFR status and survival. EGFR FISH results were significantly (P = 0.003) higher in more advanced tumours (Stages II, III and IV) than in the tumours in Stage I. Non-smokers exhibited a significantly higher EGFR gene copy number and protein overexpression in Stages I and II OTSCC than smokers (P = 0.001, P = 0.009). In conclusion, EGFR was found to be overexpressed in all OTSCCs making this cancer type interesting for exploring new therapeutic agents targeting the EGFR receptor.
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