Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo.
Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo.
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DOI：
10.1038/s42003-023-04542-6
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发表时间：
2023-02-17
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
神经血管耦合（NVC）是一种机制，除了其他已知的和潜在的关键功能，确保激活的大脑区域充分供应氧气和葡萄糖。这种生物学现象支持非侵入性灌注相关的神经成像技术，最近的报告表明，NVC损伤在几种神经退行性疾病。然而，关于NVC在健康和疾病中的作用仍有许多未知之处，直到最近才开始认识到与大脑热力学的密切相互作用。因此，我们开发了一种新的多模态方法来系统地调节皮层温度和询问感觉诱发的NVC的时空动态。我们发现，皮层温度的变化深刻而复杂地调节NVC，低温与氧气输送减少，高温诱导一个独特的血管振荡。这些观察结果为NVC和脑热力学之间的关系提供了新的见解，对脑温相关治疗，脑温升高的功能生物标志物以及研究神经血管耦合的体内方法具有重要意义。一种多模式的方法是在大鼠，这使得审讯的影响，温度变化对神经血管耦合。
Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen and glucose. This biological phenomenon underpins non-invasive perfusion-related neuroimaging techniques and recent reports have implicated NVC impairment in several neurodegenerative disorders. Yet, much remains unknown regarding NVC in health and disease, and only recently has there been burgeoning recognition of a close interplay with brain thermodynamics. Accordingly, we developed a novel multi-modal approach to systematically modulate cortical temperature and interrogate the spatiotemporal dynamics of sensory-evoked NVC. We show that changes in cortical temperature profoundly and intricately modulate NVC, with low temperatures associated with diminished oxygen delivery, and high temperatures inducing a distinct vascular oscillation. These observations provide novel insights into the relationship between NVC and brain thermodynamics, with important implications for brain-temperature related therapies, functional biomarkers of elevated brain temperature, and in-vivo methods to study neurovascular coupling. A multimodal approach is developed in rats, which enables the interrogation of effects of temperature changes on neurovascular coupling.
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影响因子：
16.6
作者：
Iturria-Medina Y;Sotero RC;Toussaint PJ;Mateos-Pérez JM;Evans AC;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
4.8
作者：
Henker, RA;Brown, SD;Marion, DW
通讯作者：
Marion, DW
影响因子：
3.3
作者：
Cairns, Chris J S;Andrews, Peter J D
通讯作者：
Andrews, Peter J D
影响因子：
3.3
作者：
Collins, CM;Smith, MB;Turner, R
通讯作者：
Turner, R
影响因子：
158.5
作者：
Bernard, SA;Gray, TW;Smith, K
通讯作者：
Smith, K