Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study.
Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study.
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DOI：
10.1016/j.neuro.2009.07.007
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发表时间：
2009-11
期刊：
影响因子：
3.4
通讯作者：
Cecil KM
中科院分区：
文献类型：
--
作者：
Brubaker CJ;Schmithorst VJ;Haynes EN;Dietrich KN;Egelhoff JC;Lindquist DM;Lanphear BP;Cecil KM
儿童期铅暴露与不良认知、神经行为和运动结果相关，表明大脑结构和功能改变。这项工作的目的是评估儿童期铅暴露对年轻成年人白色物质完整性的长期影响。我们假设儿童期铅暴露会通过轴突完整性和髓鞘组织缺陷改变成人白色物质结构。招募来自辛辛那提电极导线研究的成人（22.9 ± 1.5岁，范围20.0 - 26.1岁）进行一项采用弥散张量成像（DTI）的研究。确定了91名参与者（52名女性）白色物质中水扩散特性与平均儿童血铅水平之间关联的解剖区域。分数各向异性（FA），平均扩散率（MD），轴向扩散率（AD）和径向扩散率（RD）进行了测量的探索体素的基础上。在校正分析中，平均儿童血铅水平与整个白色物质FA降低相关。辐射冠区域表现出非常显着的铅相关的减少FA和AD和增加MD和RD。胼胝体的背侧部、体部和压部表现出高度显著的铅相关RD降低，MD降低较小且不太显著，AD增加的小区域。该分析的结果表明，在成人脑中，多次损伤表现为白色物质扩散异常的不同模式。参与者在整个童年时期经历的显著铅负荷的神经毒性损伤对神经元素的影响不同，可能与暴露期间髓鞘形成的发育阶段有关。这项研究表明，儿童期铅暴露与白色物质微观结构的显着和持久的影响，作为量化的扩散率的变化，提示髓鞘形成和轴突完整性的改变。
Childhood lead exposure is associated with adverse cognitive, neurobehavioral and motor outcomes, suggesting altered brain structure and function. The purpose of this work was to assess the long-term impact of childhood lead exposure on white matter integrity in young adults. We hypothesized that childhood lead exposure would alter adult white matter architecture via deficits in axonal integrity and myelin organization. Adults (22.9 ± 1.5 years, range 20.0 to 26.1 years) from the Cincinnati Lead Study were recruited to undergo a study employing diffusion tensor imaging (DTI). The anatomic regions of association between water diffusion characteristics in white matter and mean childhood blood lead level were determined for ninety-one participants (52 female). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured on an exploratory voxel-wise basis. In adjusted analyses, mean childhood blood lead levels were associated with decreased FA throughout white matter. Regions of the corona radiata demonstrated highly significant lead-associated decreases in FA and AD and increases in MD and RD. The genu, body, and splenium of the corpus callosum demonstrated highly significant lead-associated decreases in RD, smaller and less significant decreases in MD, and small areas with increases in AD. The results of this analysis suggest multiple insults appear as distinct patterns of white matter diffusion abnormalities in the adult brain. Neurotoxic insults from the significant lead burden the participants experienced throughout childhood affect neural elements differently and may be related to the developmental stage of myelination at periods of exposure. This study indicates that childhood lead exposure is associated with a significant and persistent impact on white matter microstructure as quantified with diffusivity changes suggestive of altered myelination and axonal integrity.
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影响因子：
2.9
作者：
Deng, WB;Poretz, RD
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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作者：
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