Early intervention for very young children with or at high likelihood for autism spectrum disorder: An overview of reviews.
Early intervention for very young children with or at high likelihood for autism spectrum disorder: An overview of reviews.
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DOI：
10.1111/dmcn.15258
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发表时间：
2022-09
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
确定哪些干预措施是有证据支持的，以及证据的质量，以改善患有或极有可能患有自闭症谱系障碍（ASD）的幼儿的儿童结局。我们进行了综述，以综合早期干预文献的非常年幼的儿童或高可能性的ASD。遵循Cochrane关于如何进行综述的指南。在2009年1月至2020年12月期间，对数据库进行了全面检索，以进行系统评价和荟萃分析。对综述资料进行提取和总结，并对方法学质量进行评估。总结了主要随机对照试验证据并评估了偏倚风险。这个综述没有注册。从762份记录中，回顾了78份全文，并确定了7项系统回顾和63项独特研究的荟萃分析。几种干预方法（自然发展行为干预和发展与行为干预）改善了儿童的发展结果。注意到设计、干预和对照组、剂量、给药剂和测量方法的异质性。发现了不一致的方法质量和潜在的偏差。虽然许多早期干预方法对儿童的预后有影响，但研究的异质性和质量影响了我们得出关于哪种治疗方法最有效的确切结论的能力。试验方法和设计的进步，以及对减轻测量偏差的日益重视，将提高ASD早期干预证据基础的质量。
To identify which interventions are supported by evidence and the quality of that evidence in very young children with or at high likelihood for autism spectrum disorder (ASD) to improve child outcomes. We conducted an overview of reviews to synthesize early intervention literature for very young children with or at high likelihood for ASD. Cochrane guidance on how to perform overviews of reviews was followed. Comprehensive searches of databases were conducted for systematic reviews and meta-analyses between January 2009 and December 2020. Review data were extracted and summarized and methodological quality was assessed. Primary randomized controlled trial evidence was summarized and risk of bias assessed. This overview of reviews was not registered. From 762 records, 78 full texts were reviewed and seven systematic reviews and meta-analyses with 63 unique studies were identified. Several interventional approaches (naturalistic developmental behavioral intervention, and developmental and behavioral interventions) improved child developmental outcomes. Heterogeneity in design, intervention and control group, dose, delivery agent, and measurement approach was noted. Inconsistent methodological quality and potential biases were identified. While many early interventional approaches have an impact on child outcomes, study heterogeneity and quality had an impact on our ability to draw firm conclusions regarding which treatments are most effective. Advances in trial methodology and design, and increasing attention to mitigating measurement bias, will advance the quality of the ASD early intervention evidence base.
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影响因子：
6.4
作者：
Drew, A;Baird, G;Charman, T
通讯作者：
Charman, T
影响因子：
2.5
作者：
Cardon, Teresa A.
通讯作者：
Cardon, Teresa A.
影响因子：
2.1
作者：
Brookman-Frazee, L
通讯作者：
Brookman-Frazee, L
影响因子：
1.4
作者：
Baril, Erika M.;Humphreys, Betsy P.
通讯作者：
Humphreys, Betsy P.
DOI：
10.1111/j.1469-7610.2010.02326.x
发表时间：
2010-12-01
影响因子：
7.6
作者：
Coolican, Jamesie;Smith, Isabel M.;Bryson, Susan E.
通讯作者：
Bryson, Susan E.