FDG PET imaging of childhood sarcomas.
FDG PET imaging of childhood sarcomas.
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DOI：
10.1002/pbc.22307
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发表时间：
2010-02
影响因子：
3.2
通讯作者：
Shulkin, Barry L.
中科院分区：
文献类型：
--
作者：
Mody, Rajen J.;Bui, Chuong;Hutchinson, Raymond J.;Yanik, Greg A.;Castle, Valerie P.;Frey, Kirk A.;Shulkin, Barry L.
使用[18F]氟脱氧葡萄糖(FDG)的正电子发射断层扫描(PET)成像对成人包括淋巴瘤在内的各种恶性肿瘤的检测、分期和监测是有用的，但它在儿童和年轻人的肉瘤，特别是软组织肉瘤(STS)中的作用尚不清楚。为了评估FDGPET在儿童和年轻人STS治疗中的潜在效用，我们分析了超过12年的25名患者的46次PET扫描。扫描是由两名成像医生解释的，他们对其他成像研究和临床信息视而不见。将结果与计算机断层扫描和磁共振成像、活检结果(如果有)以及至少12个月的临床随访结果进行比较。在25名患者的46次扫描中，25次扫描为真阳性，3次为假阳性，12次为真阴性扫描，6次为假阴性扫描。PET扫描的敏感性为86%，特异性为80%，阳性预测值为89%，阴性预测值为67%。FDGPET在儿童和青壮年STS的治疗中可能是一种有用的成像方式，尽管需要进行前瞻性研究来确定其真正的用途。
Positron-emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear. To evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and magnetic resonance imaging, biopsy results, where available, and clinical follow-up of at least 12 months. For a total of 46 scans in 25 patients, there were 25 true positive scans, 3 false positive scans, 12 true negative scans, and 6 false negative scans. The sensitivity of the PET scan was 86%, specificity was 80%, positive predictive value was 89%, and negative predictive value was 67%. FDG PET may be a useful imaging modality in the management of children and young adults with STS, although prospective studies are needed to establish its true utility.
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DOI：
10.1007/s00259-004-1645-3
发表时间：
2005-01-01
影响因子：
9.1
作者：
Wegner, EA;Barrington, SF;O'Doherty, MJ
通讯作者：
O'Doherty, MJ
影响因子：
6.2
作者：
Schuetze, SM;Rubin, BP;Eary, JF
通讯作者：
Eary, JF
DOI：
10.1097/01.mph.0000212949.12856.02
发表时间：
2006-07-01
影响因子：
1.2
作者：
Weyl Ben Arush, Myriam;Bar Shalom, Rachel;Israel, Ora
通讯作者：
Israel, Ora
影响因子：
9.3
作者：
Gerth, Hans U.;Juergens, Kai U.;Franzius, Christiane
通讯作者：
Franzius, Christiane
影响因子：
10.6
作者：
Iagaru, Andrei;Quon, Andrew;Gambhir, Sanjiv S.
通讯作者：
Gambhir, Sanjiv S.