Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer.
Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer.
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DOI：
10.1186/s13046-015-0144-7
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发表时间：
2015-03-28
期刊：
影响因子：
--
通讯作者：
Nakajima Y
中科院分区：
文献类型：
--
作者：
Nishiwada S;Sho M;Yasuda S;Shimada K;Yamato I;Akahori T;Kinoshita S;Nagai M;Konishi N;Nakajima Y
Nectin-4属于在人类中具有多种生理和病理功能的Nectin家族。最近的研究也表明了Nectin-4在几种人类癌症中的一些作用。然而，Nectin-4在肿瘤中的确切作用和临床相关性在很大程度上是未知的。应用免疫组织化学方法检测123例胰腺癌组织中Nectin-4的表达。此外，我们还通过免疫组织化学和siRNA干扰方法研究了Nectin-4在胰腺癌中与肿瘤增殖、血管生成和免疫的关系。Nectin-4高表达患者的术后预后比低表达患者差。多因素分析显示Nectin-4的表达对胰腺癌的预后有显著的独立预测价值（HR = 1.721，1.085-2.730; P = 0.021）。肿瘤组织中Nectin-4的表达与Ki 67的表达显著相关。此外，siRNA介导的Nectin-4基因沉默显著抑制人胰腺癌细胞Capan-2和BxPC-3的细胞增殖。此外，Nectin-4表达与VEGF表达和肿瘤内微血管密度呈正相关。然而，肿瘤Nectin-4表达与肿瘤浸润性T细胞无显著相关性。Nectin-4是一个重要的预后预测因子，可能在胰腺癌中发挥关键作用。Nectin-4可能成为胰腺癌治疗的新靶点。
Nectin-4 belongs to the nectin family that has diverse physiological and pathological functions in humans. Recent studies have also suggested some roles for Nectin-4 in several human cancers. However, the precise roles and clinical relevance of Nectin-4 in tumors are largely unknown. Nectin-4 expression was investigated in 123 patients with pancreatic cancer by immunohistochemistry. Furthermore, we investigated the association of Nectin-4 in pancreatic cancer with tumor proliferation, angiogenesis and immunity by using immunohistochemistry and siRNA interference method. Patients with high Nectin-4 expression had poorer postoperative prognosis than those with low expression. Importantly, multivariate analysis indicated that Nectin-4 expression had a significant independent prognostic value in pancreatic cancer (HR = 1.721, 1.085-2.730; P = 0.021). Tumor Nectin-4 expression was significantly correlated with Ki67 expression. In addition, siRNA-mediated gene silencing of Nectin-4 significantly inhibited the cell proliferation in human pancreatic cancer cells, Capan-2 and BxPC-3. Furthermore, Nectin-4 expression was also positively correlated with VEGF expression and intratumoral microvessel density. However, there were no significant correlations of tumor Nectin-4 expression with tumor-infiltrating T cells. Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.
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影响因子：
3.8
作者：
Fabre-Lafay S;Monville F;Garrido-Urbani S;Berruyer-Pouyet C;Ginestier C;Reymond N;Finetti P;Sauvan R;Adélaïde J;Geneix J;Lecocq E;Popovici C;Dubreuil P;Viens P;Gonçalves A;Charafe-Jauffret E;Jacquemier J;Birnbaum D;Lopez M
通讯作者：
Lopez M
影响因子：
8.8
作者：
Ino Y;Yamazaki-Itoh R;Shimada K;Iwasaki M;Kosuge T;Kanai Y;Hiraoka N
通讯作者：
Hiraoka N
DOI：
10.1083/jcb.200501090
发表时间：
2005-10-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fujito T;Ikeda W;Kakunaga S;Minami Y;Kajita M;Sakamoto Y;Monden M;Takai Y
通讯作者：
Takai Y
影响因子：
45.3
作者：
Moore, Malcolm J.;Goldstein, David;Parulekar, Wendy
通讯作者：
Parulekar, Wendy
影响因子：
11.5
作者：
Nomi, Takeo;Sho, Masayuki;Nakajima, Yoshiyuki
通讯作者：
Nakajima, Yoshiyuki