RNA-seq analysis of gene expression profiles in posttraumatic stress disorder, Parkinson's disease and schizophrenia identifies roles for common and distinct biological pathways.
RNA-seq analysis of gene expression profiles in posttraumatic stress disorder, Parkinson's disease and schizophrenia identifies roles for common and distinct biological pathways.
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DOI：
10.1007/s44192-022-00009-y
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发表时间：
2022-03-03
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影响因子：
--
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中科院分区：
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--
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有证据表明，神经精神疾病（NPD）的共同病理生理机制可能有助于风险和弹性。我们使用单基因和网络水平的转录组学方法来研究南非样本中创伤后应激障碍（PTSD）、帕金森病（PD）和精神分裂症的共享和特定疾病过程。对从每个群组的病例和对照获得的血液进行RNA-seq。分别使用DESeq 2和CEMiTool进行基因表达和加权基因相关网络分析（WGCNA）。基因表达的显著差异仅限于PTSD队列。然而，WGCNA暗示，除其他外，核糖体表达，炎症和泛素化是正在调查的NPD的关键参与者。在PTSD和PD队列中观察到核糖体相关通路的差异表达，并且在PD和精神分裂症中涉及粘着斑和细胞外基质通路。我们建议，尽管不同的表型介绍，核心转诊断机制可能在NPD的分子病因学中发挥重要作用。在线版本包含补充材料，可通过10.1007/s44192-022-00009-y获得。
Evidence suggests that shared pathophysiological mechanisms in neuropsychiatric disorders (NPDs) may contribute to risk and resilience. We used single-gene and network-level transcriptomic approaches to investigate shared and disorder-specific processes underlying posttraumatic stress disorder (PTSD), Parkinson’s disease (PD) and schizophrenia in a South African sample. RNA-seq was performed on blood obtained from cases and controls from each cohort. Gene expression and weighted gene correlation network analyses (WGCNA) were performed using DESeq2 and CEMiTool, respectively. Significant differences in gene expression were limited to the PTSD cohort. However, WGCNA implicated, amongst others, ribosomal expression, inflammation and ubiquitination as key players in the NPDs under investigation. Differential expression in ribosomal-related pathways was observed in the PTSD and PD cohorts, and focal adhesion and extracellular matrix pathways were implicated in PD and schizophrenia. We propose that, despite different phenotypic presentations, core transdiagnostic mechanisms may play important roles in the molecular aetiology of NPDs. The online version contains supplementary material available at 10.1007/s44192-022-00009-y.
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影响因子：
6.6
作者：
Charlson, Fiona J.;Ferrari, Alize J.;Whiteford, Harvey A.
通讯作者：
Whiteford, Harvey A.
影响因子：
3.3
作者：
Blevins, Christy A.;Weathers, Frank W.;Witte, Tracy K.
通讯作者：
Witte, Tracy K.
影响因子：
30.8
作者：
Chang D;Nalls MA;Hallgrímsdóttir IB;Hunkapiller J;van der Brug M;Cai F;International Parkinson's Disease Genomics Consortium;23andMe Research Team;Kerchner GA;Ayalon G;Bingol B;Sheng M;Hinds D;Behrens TW;Singleton AB;Bhangale TR;Graham RR
通讯作者：
Graham RR
影响因子：
11
作者：
Arion, D.;Corradi, J. P.;Tang, S.;Datta, D.;Boothe, F.;He, A.;Cacace, A. M.;Zaczek, R.;Albright, C. F.;Tseng, G.;Lewis, D. A.
通讯作者：
Lewis, D. A.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y