Taenia crassiceps infection attenuates multiple low-dose streptozotocin-induced diabetes.
Taenia crassiceps infection attenuates multiple low-dose streptozotocin-induced diabetes.
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DOI：
10.1155/2010/850541
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发表时间：
2010
影响因子：
--
通讯作者：
Terrazas LI
中科院分区：
文献类型：
--
作者：
Espinoza-Jiménez A;Rivera-Montoya I;Cárdenas-Arreola R;Morán L;Terrazas LI
粗头绦虫和其他蠕虫一样，可以对其宿主的免疫系统产生调节作用。本研究探讨了慢性T。粗头绦虫感染对多次低剂量链脲佐菌素诱导的糖尿病（MLDS）结局的影响。健康或以前的T。感染巨足线虫的小鼠接受MLDS，并在MLDS诱导后评价1型糖尿病（T1 D）症状6周。T.在整个研究过程中，感染了巨足线虫的小鼠显示出较低的血糖水平。T.与未感染组（100%）相比，感染厚壳绦虫的小鼠（40%）发展为T1 D。T.感染厚壳绦虫的小鼠，其胰腺胰岛素含量正常，而未感染的小鼠显示胰腺胰岛素急剧减少。接受MLDS的感染小鼠没有显示出其调节性T细胞群的增加，但是，它们具有更多的交替激活的巨噬细胞，更高水平的细胞因子IL-4和更低水平的TNF-α。因此，T.粗头绦虫引起免疫调节，改变MLDS诱导的自身免疫性糖尿病的发生和发展。
Taenia crassiceps, like other helminths, can exert regulatory effects on the immune system of its host. This study investigates the effect of chronic T. crassiceps infection on the outcome of Multiple Low Dose Streptozotocin-Induced Diabetes (MLDS). Healthy or previously T. crassiceps-infected mice received MLDS and type 1 diabetes (T1D) symptoms were evaluated for 6 weeks following the induction of MLDS. T. crassiceps-infected mice displayed lower blood glucose levels throughout the study. A significantly lower percentage of T. crassiceps-infected mice (40%) developed T1D compared to the uninfected group (100%). Insulitis was remarkably absent in T. crassiceps-infected mice, which had normal pancreatic insulin content, whereas uninfected mice showed a dramatic reduction in pancreatic insulin. Infected mice that received MLDS did not show an increase in their regulatory T cell population, however, they had a greater number of alternatively activated macrophages, higher levels of the cytokine IL-4, and lower levels of TNF-α. Therefore, infection with T. crassiceps causes an immunomodulation that modifies the incidence and development of MLDS-induced autoimmune diabetes.
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影响因子：
1.5
作者：
Hewitson, James P.;Grainger, John R.;Maizels, Rick M.
通讯作者：
Maizels, Rick M.
DOI：
10.1084/jem.178.1.87
发表时间：
1993-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Rapoport MJ;Jaramillo A;Zipris D;Lazarus AH;Serreze DV;Leiter EH;Cyopick P;Danska JS;Delovitch TL
通讯作者：
Delovitch TL
影响因子：
3.1
作者：
Rausch, Sebastian;Huehn, Jochen;Hartmann, Susanne
通讯作者：
Hartmann, Susanne
影响因子：
3.1
作者：
Nookala, S;Srinivasan, S;Nutman, TB
通讯作者：
Nutman, TB
影响因子：
5.4
作者：
Elliott, DE;Setiawan, T;Weinstock, JV
通讯作者：
Weinstock, JV