Contour integration deficits at high spatial frequencies in children treated for anisometropic amblyopia.
Contour integration deficits at high spatial frequencies in children treated for anisometropic amblyopia.
复制标题
屈光参差性弱视治疗儿童在高空间频率下的轮廓整合缺陷。
DOI：
10.3389/fnins.2023.1160853
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发表时间：
2023
影响因子：
4.3
通讯作者：
Zhang, Jun-Yun
中科院分区：
文献类型：
--
作者：
Jiang, Shu-Qi;Chen, Yan-Ru;Liu, Xiang-Yun;Zhang, Jun-Yun
本研究旨在重新探讨屈光参差性弱视患儿是否存在轮廓整合缺陷。为此，我们使用了心理物理学方法，这些方法需要全局轮廓处理，同时最大限度地减少低水平缺陷的影响：可见性，形状感知和位置不确定性。13名屈光参差性弱视儿童（年龄：10.1 ± 1.8岁）和13名视力正常儿童（年龄：10.8 ± 2.0岁）参加了这项研究。刺激是在噪声或空白场中由Gabor贴片组成的封闭图形。在Gabor空间频率为1.5、3和6 cpd时，测量弱视眼（AE）、对侧眼（FE）和正常对照眼在空白视野中检测圆形轮廓的对比度阈值，以及在噪声中辨别圆形或椭圆形轮廓的纵横比和轮廓元素数阈值。测试前测量AE和FE的视力和对比敏感度功能以及Randot立体视敏度。与较高空间频率（6 cpd）下的FE相比，AE显示出对比度不足和形状感知下降。当异常对比敏感度和形状感知的影响最小化时，AE在空间频率3和6 cpd处显示轮廓整合缺陷。这些缺陷与对比敏感度和锐度、立体视锐度和视觉拥挤的基本丧失无关。弱视儿童的对侧眼与正常对照眼在轮廓整合方面无显著性差异。在消除或补偿了低水平的缺陷后，屈光参差性弱视治疗的儿童仍然显示轮廓整合缺陷，主要是在较高的空间频率，这可能反映了弱视引起的全局处理缺陷。轮廓整合缺陷可能独立于空间视觉缺陷。屈光矫正和/或遮挡治疗可能不足以完全恢复轮廓整合缺陷，这表明需要开发临床治疗来恢复这些缺陷。
This study was conducted to reexamine the question of whether children treated for anisometropic amblyopia have contour integration deficits. To do so, we used psychophysical methods that require global contour processing while minimizing the influence of low-level deficits: visibility, shape perception, and positional uncertainty. Thirteen children with anisometropic amblyopia (age: 10.1 ± 1.8 years) and thirteen visually normal children (age: 10.8 ± 2.0 years) participated in this study. The stimuli were closed figures made up of Gabor patches either in noise or on a blank field. The contrast thresholds to detect a circular contour on a blank field, as well as the thresholds of aspect ratio and contour element number to discriminate a circular or elliptical contour in noise, were measured at Gabor spatial frequencies of 1.5, 3, and 6 cpd for amblyopic eyes (AEs), fellow eyes (FEs), and normal control eyes. Visual acuities and contrast sensitivity functions for AEs and FEs and the Randot stereoacuity were measured before testing. The AEs showed contrast deficits and degraded shape perception compared to the FEs at higher spatial frequencies (6 cpd). When the influence of abnormal contrast sensitivity and shape perception were minimized, the AEs showed contour integration deficits at spatial frequencies 3 and 6 cpd. These deficits were not related to basic losses in contrast sensitivity and acuity, stereoacuity, and visual crowding. Besides, no significant difference was found between the fellow eyes of the amblyopic children and the normal control eyes in the performance of contour integration. After eliminating or compensating for the low-level deficits, children treated for anisometropic amblyopia still show contour integration deficits, primarily at higher spatial frequencies, which might reflect the deficits in global processing caused by amblyopia. Contour integration deficits are likely independent of spatial vision deficits. Refractive correction and/or occlusion therapies may not be sufficient to fully restore contour integration deficits, which indicates the need for the development of clinical treatments to recover these deficits.
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影响因子：
3.8
作者：
Hamm LM;Black J;Dai S;Thompson B
通讯作者：
Thompson B
DOI：
10.1523/jneurosci.3055-10.2010
发表时间：
2010-09-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
El-Shamayleh Y;Kiorpes L;Kohn A;Movshon JA
通讯作者：
Movshon JA
影响因子：
16.2
作者：
Gilad, Ariel;Meirovithz, Elhanan;Slovin, Hamutal
通讯作者：
Slovin, Hamutal
影响因子：
1.8
作者：
Demanins, R;Hess, RF
通讯作者：
Hess, RF
影响因子：
17.8
作者：
Birch EE
通讯作者：
Birch EE