The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow.
The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow.
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DOI：
10.1016/j.cmet.2018.02.016
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发表时间：
2018-03-06
期刊：
影响因子：
29
通讯作者：
Caicedo A
中科院分区：
文献类型：
--
作者：
Almaça J;Weitz J;Rodriguez-Diaz R;Pereira E;Caicedo A
有效的胰岛素分泌需要功能良好的胰岛微脉管系统。胰岛毛细血管的密集网络包括几乎没有研究的细胞胰岛周细胞。在这里，我们表明胰岛周细胞通过调节胰岛毛细管直径来帮助控制局部血流。胰岛周细胞覆盖40％的微脉管系统，是收缩的，并且由交感神经轴突支配。交感神经能力输入增加周细胞活性，并降低毛细血管直径和局部血流。相比之下，通过增加葡萄糖浓度来激活β细胞会抑制周细胞，扩张胰岛毛细血管并增加局部血流。这些对周细胞的作用是由内源性腺苷介导的，内源性腺苷可能来自ATP与胰岛素共发行。胰岛毛细血管的周细胞覆盖范围在2型糖尿病中急剧下降，这表明在糖尿病状况下，胰岛失去了控制自己的血液供应的机制。这可能导致胰岛素释放不足，从而进一步恶化血糖控制。
XXX等人研究胰岛胰岛中的周围的周围细胞（将毛细血管内皮细胞包裹起来），并显示胰岛周细胞通过调节胰岛毛细管直径有助于控制局部血液流动。他们进一步表明，这种机制在糖尿病中丢失，可能导致胰岛素供应不足。
Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The dense network of islet capillaries includes the islet pericyte, a cell that has barely been studied. Here we show that islet pericytes help control local blood flow by adjusting islet capillary diameter. Islet pericytes cover 40% of the microvasculature, are contractile, and are innervated by sympathetic axons. Sympathetic adrenergic input increases pericyte activity and reduces capillary diameter and local blood flow. By contrast, activating beta cells by increasing glucose concentration inhibits pericytes, dilates islet capillaries, and increases local blood flow. These effects on pericytes are mediated by endogenous adenosine, which is likely derived from ATP co-released with insulin. Pericyte coverage of islet capillaries drops drastically in type 2 diabetes, suggesting that, under diabetic conditions, islets lose this mechanism to control their own blood supply. This may lead to inadequate insulin release into the circulation, further deteriorating glycemic control. XXX et al study pericyte cells, which wrap around capillary endothelial cells, in the islets of the pancreas and show that islet pericytes help control local blood flow by adjusting islet capillary diameter. They further show that this mechanism in lost in diabetes, which may lead to inadequate insulin supply.
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影响因子：
4
作者：
Borysova L;Burdyga T
通讯作者：
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影响因子：
4
作者：
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10.1152/ajpendo.00044.2002
发表时间：
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影响因子：
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