Angiotensin-converting enzyme in discrete areas of the rat forebrain and pituitary gland
Angiotensin-converting enzyme in discrete areas of the rat forebrain and pituitary gland
复制标题
大鼠前脑和垂体离散区域中的血管紧张素转换酶
DOI：
10.1016/0006-8993(82)90814-9
复制
发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
C. Chevillard
中科院分区：
文献类型：
--
作者：
J. Saavedra;J. Fernandez;C. Chevillard
利用灵敏的放射性同位素方法，我们检测了大鼠前脑特定核和大鼠脑垂体前叶、中间叶和后叶的血管紧张素转换酶（ACE， E.C. 3.4.15.1）的活性。我们报道了ACE活性在大鼠前脑的分布是不均匀的，最低和最高的值相差200倍。酶活性最高的部位是皮质下器官和脑垂体后叶。脑垂体的中间叶和前叶、尾状核和内侧束核也检测到高ACE活性。苍白球、正中隆起、视上核和室旁核、外侧束核和终层血管器也存在大量活动。我们的研究结果表明，肾素-血管紧张素系统的组成部分之一，血管紧张素转换酶，高度定位于几个离散的脑结构和脑垂体。这些发现表明血管紧张素II可能在这些结构中局部形成，支持先前的免疫组织化学数据。
With the use of a sensitive radioisotopic method we have examined the activity of the angiotensin-converting enzyme (ACE, E.C. 3.4.15.1) in specific nuclei of the rat forebrain and in the anterior, intermediate and posterior lobes of the pituitary gland of the rat.We reported that ACE activity is heterogenously distributed in the rat forebrain, with a 200-fold difference between the lowest and the highest values. Highest enzyme activities were found in the subfornical organ and in the posterior lobe of the pituitary gland. High ACE activity was also detected in the intermediate and anterior lobes of the pituitary gland, the caudate nucleus, and the medial habenular nucleus. Substantial activity also existed in the globus pallidus, the median eminence, the supraoptic and paraventricular nuclei, the lateral habenular nucleus and the organon vasculosum laminae terminalis.Our results demonstrate that one of the components of the renin-angiotensin system, the angiotensin-converting enzyme, is highly localized to a few discrete brain structures and the pituitary gland. These findings suggest that angiotensin II could be formed locally in some of these structures, supporting previous immunohistochemical data.
血管紧张素II对雌性大鼠体内和体外垂体前叶激素释放的影响。
影响因子：
4.8
作者：
Steele,MK;Negro-Vilar,A;McCann,SM
通讯作者：
McCann,SM
影响因子：
56.9
作者：
S. Landas;M. Phillips;J. Stamler;M. Raizada
通讯作者：
S. Landas;M. Phillips;J. Stamler;M. Raizada