Characterization of plasma thiol redox potential in a common marmoset model of aging.
Characterization of plasma thiol redox potential in a common marmoset model of aging.
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DOI：
10.1016/j.redox.2013.06.003
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发表时间：
2013
期刊：
影响因子：
11.4
通讯作者：
Jones, Dean P.
中科院分区：
文献类型：
--
作者：
Roede, James R.;Uppal, Karan;Liang, Yongliang;Promislow, Daniel E. L.;Wachtman, Lynn M.;Jones, Dean P.
Due to its short lifespan, ease of use and age-related pathologies that mirror those observed in humans, the common marmoset (Callithrix jacchus) is poised to become a standard nonhuman primate model of aging. Blood and extracellular fluid possess two major thiol-dependent redox nodes involving cysteine (Cys), cystine (CySS), glutathione (GSH) and glutathione disulfide (GSSG). Alteration in these plasma redox nodes significantly affects cellular physiology, and oxidation of the plasma Cys/CySS redox potential (EhCySS) is associated with aging and disease risk in humans. The purpose of this study was to determine age-related changes in plasma redox metabolites and corresponding redox potentials (Eh) to further validate the marmoset as a nonhuman primate model of aging. We measured plasma thiol redox states in marmosets and used existing human data with multivariate adaptive regression splines (MARS) to model the relationships between age and redox metabolites. A classification accuracy of 70.2% and an AUC of 0.703 were achieved using the MARS model built from the marmoset redox data to classify the human samples as young or old. These results show that common marmosets provide a useful model for thiol redox biology of aging. Characterization of the Common Marmoset as a model for aging research. Plasma thiol redox measurements in marmosets ranging in age from 2–16 years. Similar to humans, marmosets exhibit age-related alterations in plasma thiol redox metabolites. Marmoset redox data can be used to classify humans as young or old.
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影响因子：
4.4
作者：
Jiang, SN;Moriarty-Craige, SE;Jones, DP
通讯作者：
Jones, DP
DOI：
10.1007/s11306-011-0332-1
发表时间：
2013-03
期刊：
Metabolomics : Official journal of the Metabolomic Society
影响因子：
--
作者：
Soltow QA;Strobel FH;Mansfield KG;Wachtman L;Park Y;Jones DP
通讯作者：
Jones DP
影响因子：
3.7
作者：
Iyer SS;Accardi CJ;Ziegler TR;Blanco RA;Ritzenthaler JD;Rojas M;Roman J;Jones DP
通讯作者：
Jones DP
影响因子：
7.4
作者：
Jonas, CR;Ziegler, TR;Jones, DP
通讯作者：
Jones, DP
影响因子：
7.4
作者：
Jones, DP;Carlson, JL;Sternberg, P
通讯作者：
Sternberg, P