Cysteine redox potential determines pro-inflammatory IL-1beta levels.
Cysteine redox potential determines pro-inflammatory IL-1beta levels.
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DOI：
10.1371/journal.pone.0005017
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Jones DP
中科院分区：
文献类型：
--
作者：
Iyer SS;Accardi CJ;Ziegler TR;Blanco RA;Ritzenthaler JD;Rojas M;Roman J;Jones DP
Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (Eh) of Cys/CySS is centered at approximately −80 mV in the plasma of healthy adults, and oxidation of Eh Cys/CySS is implicated in inflammation associated with various diseases. The purpose of the present study was to determine whether oxidized Eh Cys/CySS is a determinant of interleukin (IL)-1β levels. Results showed a 1.7-fold increase in secreted pro-IL-1β levels in U937 monocytes exposed to oxidized Eh Cys/CySS (−46 mV), compared to controls exposed to a physiological Eh of −80 mV (P<0.01). In LPS-challenged mice, preservation of plasma Eh Cys/CySS from oxidation by dietary sulfur amino acid (SAA) supplementation, was associated with a 1.6-fold decrease in plasma IL-1β compared to control mice fed an isonitrogenous SAA-adequate diet (P<0.01). Analysis of Eh Cys/CySS and IL-1β in human plasma revealed a significant positive association between oxidized Eh Cys/CySS and IL-1β after controlling for age, gender, and BMI (P<0.001). These data show that oxidized extracellular Eh Cys/CySS is a determinant of IL-1β levels, and suggest that strategies to preserve Eh Cys/CySS may represent a means to control IL-1β in inflammatory disease states.
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DOI：
10.1152/ajpregu.00195.2007
发表时间：
2007-09-01
影响因子：
2.8
作者：
Anderson, Corinna L.;Iyer, Smita S.;Jones, Dean P.
通讯作者：
Jones, Dean P.
影响因子：
7.4
作者：
Moriarty, SE;Shah, JH;Sternberg, P
通讯作者：
Sternberg, P
影响因子：
6
作者：
Fan, Zhiyong;Soeder, Stephan;Aigner, Thomas
通讯作者：
Aigner, Thomas
影响因子：
7.1
作者：
Blanco, Roberto A.;Ziegler, Thomas R.;Jones, Dean P.
通讯作者：
Jones, Dean P.
影响因子：
4.4
作者：
Jiang, SN;Moriarty-Craige, SE;Jones, DP
通讯作者：
Jones, DP